Q73JP8 (SELD_TREDE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Selenide, water dikinase
EC=2.7.9.3

Alternative name(s):
Selenium donor protein
Selenophosphate synthase

Gene names

Name:	selD
Ordered Locus Names:	TDE_2461

Organism

Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]

Taxonomic identifier

243275 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP By similarity. HAMAP MF_00625
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate. HAMAP MF_00625
Cofactor	Magnesium By similarity. HAMAP MF_00625
Sequence similarities	Belongs to the selenophosphate synthase 1 family. Class I subfamily.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	ATP-binding Magnesium Nucleotide-binding Selenium
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW selenide, water dikinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Selenide, water dikinase HAMAP MF_00625		PRO_0000127642
Regions
	Nucleotide binding	232 – 238	7	ATP Potential
Sites
	Active site	21	1	Potential
	Site	24	1	Important for catalytic activity By similarity
Amino acid modifications
	Non-standard residue	21	1	Selenocysteine HAMAP MF_00625

Sequences

	Sequence		Length	Mass (Da)
	Q73JP8 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 043720C8C7467F12	FASTA	354	38,311
	10 20 30 40 50 60 MSCSLINEDF DLLKAAKNPG UGAKLSAGAL DKLLKNFSVR NDDNLLVGFN TSDDAAVYKI 70 80 90 100 110 120 NDKTALISTI DFFPPVSGDP YIFGQVAAAN SLSDIYAMGG EPKLALNLFC ITKDMPEDMI 130 140 150 160 170 180 KEILRGGFDK VYEAGAIVCG GHTIYDDSPK YGLAVNGFVH PKKILENSTA KEGDVLILTK 190 200 210 220 230 240 PIGTGILLTA SKADMSPPEE LDRCYKIMAF LNAKARNIMV KYKINACTDI TGFGLLGHLY 250 260 270 280 290 300 EMGKGSGMSI EVDYKSVPIY KSVIESAEMG MMPAGVYSNR NFVGDNIVFE NVPLAYQDLM 310 320 330 340 350 FDPQTSGGLL ISVDKEDAAA LYEELSQALE NTPCGKPAII GLVTKRDEKI LRVS

References

[1]

"Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes." Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F., Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C., Shetty J. , Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004) [PubMed: 15064399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017226 Genomic DNA. Translation: AAS12978.1.
RefSeq	NP_973059.1. NC_002967.9.
3D structure databases
ProteinModelPortal	Q73JP8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2739646.
GenomeReviews	Gene locus TDE_2461 in contig AE017226_GR.
KEGG	tde:TDE2461.
PATRIC	20526996. VBITreDen445_2328.
TIGR	TDE_2461.
Phylogenomic databases
HOGENOM	HBG383791.
OMA	GGHTIED.
Enzyme and pathway databases
BioCyc	TDEN243275:TDE_2461-MONOMER.
Family and domain databases
HAMAP	MF_00625. SelD. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR004536. SelD. IPR023061. SelD_I. [Graphical view]
KO	K01008.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00476. SelD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SELD_TREDE

Accession

Primary (citable) accession number: Q73JP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program