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Q73JN2 (DDL_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:TDE_2385
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341191

Regions

Domain141 – 350210ATP-grasp
Nucleotide binding176 – 23156ATP By similarity

Sites

Metal binding3031Magnesium or manganese 1 By similarity
Metal binding3171Magnesium or manganese 1 By similarity
Metal binding3171Magnesium or manganese 2 By similarity
Metal binding3191Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73JN2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 231B8CE39A55FD34

FASTA36841,197
        10         20         30         40         50         60 
MNIAIIYGGK SSEHEVSLQS ASSIIRTIDK KHKLHLIGIS KNGAWYLHGD EERERIIKNE 

        70         80         90        100        110        120 
KAVLKIKKDE AKRVTVIPGG GAKKGLKAGD EFLPTDAVFA VLHGRFGEDG TIQGLFEMAD 

       130        140        150        160        170        180 
LPYVGGDVMS TSISMDKEKT KMIWDYSGLP IVPYIAIKRQ DWDDPEKKKA ILARAEKDLE 

       190        200        210        220        230        240 
YPLFIKPCRA GSSVGAGMVK NRNELLEQAE ESFLWDNKIL VEACIEAREV ECSVTGNTKT 

       250        260        270        280        290        300 
VAYIPGEIIP THKFYDYEAK YTDPNGAELK IPADLNETQR KTIRETAIKA YEALDLSGLS 

       310        320        330        340        350        360 
RVDFFIDKRT GKIYLNEVNT IPGFTAISMF PKMCGASGLP YNELIMHLIE LAIDRFKTDR 


KLKTCRQS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS12903.1.
RefSeqNP_972984.1. NC_002967.9.

3D structure databases

ProteinModelPortalQ73JN2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE2385.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS12903; AAS12903; TDE_2385.
GeneID2740687.
KEGGtde:TDE2385.
PATRIC20526842. VBITreDen445_2253.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OMARSAYGIY.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-2427-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_TREDE
AccessionPrimary (citable) accession number: Q73JN2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways