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Q73IU2

- AMPA_WOLPM

UniProt

Q73IU2 - AMPA_WOLPM

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Wolbachia pipientis wMel
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi261 – 2611Manganese 2UniRule annotation
    Metal bindingi266 – 2661Manganese 1UniRule annotation
    Metal bindingi266 – 2661Manganese 2UniRule annotation
    Active sitei273 – 2731UniRule annotation
    Metal bindingi284 – 2841Manganese 2UniRule annotation
    Metal bindingi343 – 3431Manganese 1UniRule annotation
    Metal bindingi345 – 3451Manganese 1UniRule annotation
    Metal bindingi345 – 3451Manganese 2UniRule annotation
    Active sitei347 – 3471UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciWEND163164:GJ8W-55-MONOMER.

    Protein family/group databases

    MEROPSiM17.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
    Short name:
    LAPUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotation
    Ordered Locus Names:WD_0054
    OrganismiWolbachia pipientis wMel
    Taxonomic identifieri163164 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000008215: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Probable cytosol aminopeptidasePRO_0000165814Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi163164.WD0054.

    Structurei

    3D structure databases

    ProteinModelPortaliQ73IU2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243129.
    KOiK01255.
    OMAiDSQFADM.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q73IU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYSLQLFATE IPAMKITISK ISPDFKTIVM GLFEDNETVN DGGVLQGKQV    50
    IDNIKQFSDF NGSFGEFFST ALPEEKNVIV VGLGKKDEWN ENKELNIGGK 100
    IYCELSRLKI KKAAVLIEGS AANVAYGAFL RSFKFDKYKT KKDEKITEVE 150
    EITVLVKDEQ LSNAERSFEH LRQEGESIFL ARSFITEPPN ILYPESYADH 200
    IKKELTKLGL EIEVLDKKQM EEKKMGALLG VAQGSSKEPK LVVIKWNGAS 250
    KEQKPIAFVG KGITFDTGGV SLKPSRGMES MKYDMAGSAT VVGVMHALAG 300
    RKAKVNAIGV VALAENAVGG NAQRPSDVVT SMSGQTIEVL NTDAEGRLIL 350
    ADALWYTQDR FSPKFMIDLA TLTGAIVVAL GNNEYAGLFS NNDELANRLI 400
    DAGNEVNEKL WRFPMNETYD KIIDSPIADV QNIAPAGSGG DSIMAAQFLQ 450
    RFVNETCWAH LDIAGTAWHE KGTDICPRGA VGFGVRLLNK LVEKYYEAND 500
    Length:500
    Mass (Da):54,922
    Last modified:July 5, 2004 - v1
    Checksum:iC82ECF4D51EFEFB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017196 Genomic DNA. Translation: AAS13818.1.
    RefSeqiNP_965884.1. NC_002978.6.
    WP_010962337.1. NC_002978.6.

    Genome annotation databases

    EnsemblBacteriaiAAS13818; AAS13818; WD_0054.
    GeneIDi2738311.
    KEGGiwol:WD0054.
    PATRICi24028675. VBIWolEnd21207_0053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017196 Genomic DNA. Translation: AAS13818.1 .
    RefSeqi NP_965884.1. NC_002978.6.
    WP_010962337.1. NC_002978.6.

    3D structure databases

    ProteinModelPortali Q73IU2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 163164.WD0054.

    Protein family/group databases

    MEROPSi M17.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS13818 ; AAS13818 ; WD_0054 .
    GeneIDi 2738311.
    KEGGi wol:WD0054.
    PATRICi 24028675. VBIWolEnd21207_0053.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243129.
    KOi K01255.
    OMAi DSQFADM.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci WEND163164:GJ8W-55-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiAMPA_WOLPM
    AccessioniPrimary (citable) accession number: Q73IU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3