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Q73IU2

- AMPA_WOLPM

UniProt

Q73IU2 - AMPA_WOLPM

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Protein
Probable cytosol aminopeptidase
Gene
pepA, WD_0054
Organism
Wolbachia pipientis wMel
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi261 – 2611Manganese 2 By similarity
Metal bindingi266 – 2661Manganese 1 By similarity
Metal bindingi266 – 2661Manganese 2 By similarity
Active sitei273 – 2731 Reviewed prediction
Metal bindingi284 – 2841Manganese 2 By similarity
Metal bindingi343 – 3431Manganese 1 By similarity
Metal bindingi345 – 3451Manganese 1 By similarity
Metal bindingi345 – 3451Manganese 2 By similarity
Active sitei347 – 3471 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciWEND163164:GJ8W-55-MONOMER.

Protein family/group databases

MEROPSiM17.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:WD_0054
OrganismiWolbachia pipientis wMel
Taxonomic identifieri163164 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000008215: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Probable cytosol aminopeptidaseUniRule annotation
PRO_0000165814Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi163164.WD0054.

Structurei

3D structure databases

ProteinModelPortaliQ73IU2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243129.
KOiK01255.
OMAiDSQFADM.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73IU2-1 [UniParc]FASTAAdd to Basket

« Hide

MYSLQLFATE IPAMKITISK ISPDFKTIVM GLFEDNETVN DGGVLQGKQV    50
IDNIKQFSDF NGSFGEFFST ALPEEKNVIV VGLGKKDEWN ENKELNIGGK 100
IYCELSRLKI KKAAVLIEGS AANVAYGAFL RSFKFDKYKT KKDEKITEVE 150
EITVLVKDEQ LSNAERSFEH LRQEGESIFL ARSFITEPPN ILYPESYADH 200
IKKELTKLGL EIEVLDKKQM EEKKMGALLG VAQGSSKEPK LVVIKWNGAS 250
KEQKPIAFVG KGITFDTGGV SLKPSRGMES MKYDMAGSAT VVGVMHALAG 300
RKAKVNAIGV VALAENAVGG NAQRPSDVVT SMSGQTIEVL NTDAEGRLIL 350
ADALWYTQDR FSPKFMIDLA TLTGAIVVAL GNNEYAGLFS NNDELANRLI 400
DAGNEVNEKL WRFPMNETYD KIIDSPIADV QNIAPAGSGG DSIMAAQFLQ 450
RFVNETCWAH LDIAGTAWHE KGTDICPRGA VGFGVRLLNK LVEKYYEAND 500
Length:500
Mass (Da):54,922
Last modified:July 5, 2004 - v1
Checksum:iC82ECF4D51EFEFB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017196 Genomic DNA. Translation: AAS13818.1.
RefSeqiNP_965884.1. NC_002978.6.
WP_010962337.1. NC_002978.6.

Genome annotation databases

EnsemblBacteriaiAAS13818; AAS13818; WD_0054.
GeneIDi2738311.
KEGGiwol:WD0054.
PATRICi24028675. VBIWolEnd21207_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017196 Genomic DNA. Translation: AAS13818.1 .
RefSeqi NP_965884.1. NC_002978.6.
WP_010962337.1. NC_002978.6.

3D structure databases

ProteinModelPortali Q73IU2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 163164.WD0054.

Protein family/group databases

MEROPSi M17.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS13818 ; AAS13818 ; WD_0054 .
GeneIDi 2738311.
KEGGi wol:WD0054.
PATRICi 24028675. VBIWolEnd21207_0053.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243129.
KOi K01255.
OMAi DSQFADM.
OrthoDBi EOG6FV8B3.

Enzyme and pathway databases

BioCyci WEND163164:GJ8W-55-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAMPA_WOLPM
AccessioniPrimary (citable) accession number: Q73IU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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