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Q73IU2

- AMPA_WOLPM

UniProt

Q73IU2 - AMPA_WOLPM

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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Wolbachia pipientis wMel
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi261 – 2611Manganese 2UniRule annotation
Metal bindingi266 – 2661Manganese 1UniRule annotation
Metal bindingi266 – 2661Manganese 2UniRule annotation
Active sitei273 – 2731UniRule annotation
Metal bindingi284 – 2841Manganese 2UniRule annotation
Metal bindingi343 – 3431Manganese 1UniRule annotation
Metal bindingi345 – 3451Manganese 1UniRule annotation
Metal bindingi345 – 3451Manganese 2UniRule annotation
Active sitei347 – 3471UniRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciWEND163164:GJ8W-55-MONOMER.

Protein family/group databases

MEROPSiM17.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
Short name:
LAPUniRule annotation
Leucyl aminopeptidaseUniRule annotation
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:WD_0054
OrganismiWolbachia pipientis wMel
Taxonomic identifieri163164 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000008215: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Probable cytosol aminopeptidasePRO_0000165814Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi163164.WD0054.

Structurei

3D structure databases

ProteinModelPortaliQ73IU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243129.
KOiK01255.
OMAiDSQFADM.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73IU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYSLQLFATE IPAMKITISK ISPDFKTIVM GLFEDNETVN DGGVLQGKQV
60 70 80 90 100
IDNIKQFSDF NGSFGEFFST ALPEEKNVIV VGLGKKDEWN ENKELNIGGK
110 120 130 140 150
IYCELSRLKI KKAAVLIEGS AANVAYGAFL RSFKFDKYKT KKDEKITEVE
160 170 180 190 200
EITVLVKDEQ LSNAERSFEH LRQEGESIFL ARSFITEPPN ILYPESYADH
210 220 230 240 250
IKKELTKLGL EIEVLDKKQM EEKKMGALLG VAQGSSKEPK LVVIKWNGAS
260 270 280 290 300
KEQKPIAFVG KGITFDTGGV SLKPSRGMES MKYDMAGSAT VVGVMHALAG
310 320 330 340 350
RKAKVNAIGV VALAENAVGG NAQRPSDVVT SMSGQTIEVL NTDAEGRLIL
360 370 380 390 400
ADALWYTQDR FSPKFMIDLA TLTGAIVVAL GNNEYAGLFS NNDELANRLI
410 420 430 440 450
DAGNEVNEKL WRFPMNETYD KIIDSPIADV QNIAPAGSGG DSIMAAQFLQ
460 470 480 490 500
RFVNETCWAH LDIAGTAWHE KGTDICPRGA VGFGVRLLNK LVEKYYEAND
Length:500
Mass (Da):54,922
Last modified:July 5, 2004 - v1
Checksum:iC82ECF4D51EFEFB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017196 Genomic DNA. Translation: AAS13818.1.
RefSeqiNP_965884.1. NC_002978.6.
WP_010962337.1. NC_002978.6.

Genome annotation databases

EnsemblBacteriaiAAS13818; AAS13818; WD_0054.
GeneIDi2738311.
KEGGiwol:WD0054.
PATRICi24028675. VBIWolEnd21207_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017196 Genomic DNA. Translation: AAS13818.1 .
RefSeqi NP_965884.1. NC_002978.6.
WP_010962337.1. NC_002978.6.

3D structure databases

ProteinModelPortali Q73IU2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 163164.WD0054.

Protein family/group databases

MEROPSi M17.950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS13818 ; AAS13818 ; WD_0054 .
GeneIDi 2738311.
KEGGi wol:WD0054.
PATRICi 24028675. VBIWolEnd21207_0053.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243129.
KOi K01255.
OMAi DSQFADM.
OrthoDBi EOG6FV8B3.

Enzyme and pathway databases

BioCyci WEND163164:GJ8W-55-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAMPA_WOLPM
AccessioniPrimary (citable) accession number: Q73IU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3