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Q73IT7

- SYL_WOLPM

UniProt

Q73IT7 - SYL_WOLPM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia pipientis wMel
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei614 – 6141ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciWEND163164:GJ8W-60-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:WD_0060
    OrganismiWolbachia pipientis wMel
    Taxonomic identifieri163164 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
    ProteomesiUP000008215: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 838838Leucine--tRNA ligasePRO_0000152118Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi163164.WD0060.

    Structurei

    3D structure databases

    ProteinModelPortaliQ73IT7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi611 – 6155"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q73IT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDFKSVEK FYQDKWDFSV SKSGKQEKCY VLEMFPYPSG KIHMGHLRNY    50
    AIGDVIARYK RANGFEVLHP IGWDAFGLPA ENAARDNNIS PETWTKENID 100
    NMRTQLKSIG LSYNWERELS TCEPDYYKHE QKFFLDFLKH GLAYRKESWV 150
    NWDPVDQTVL ANEQVVDGKG WRSGAVVEKR KLSQWFLKIT DFAEDLLKCL 200
    QSLKNWPEKV KTMQERWIGK SEGATIEFEV VGLNKKLKVF TTYPHTLFGA 250
    SFCAVAAEHP IVQDLKNGSS VVIPVLDTGI QEIKSKREND EKIGVYTGLN 300
    VKHPFLDKEL PLYIANFVLM EYGEGAIFGC PAHDQRDFEF AQKYNLPIIP 350
    VISSAHLGVI PARDQNSYNG SQCQATQMTK EAYTGDGTMF NSEFLNGLMV 400
    SEAKEAIVKK FEEKKIGKKT INYRLHDWGV SRQRYWGCPI PIIYCKDCGT 450
    VPVPEKDLPV VLPIDVEFTS GGNPLDKHPT WKFVDCPKCG KQAERETDTF 500
    DTFFESSWYF AAFCSEDKSI DKDACNRFMP VDYYIGGIEH AILHLLYSRF 550
    FCRALTKCGY FDIKEPFSTL ITQGMVCHAT YKDENGKWLF PAEAKELIAR 600
    GAKVQVGKVE KMSKSKKNTV DPNFIIEKYG ADTARLFVLS DTPPEKDMEW 650
    SDDGVEGCSR YVNKLWRMVM QLRPVNIHYD NENVTGGLLE YRKKIHKLLH 700
    GLTDDLENCR LNCVVAKFRE MTNLIAEIDV KTGKSLIDEG ICILIRVIEP 750
    FIPHLAESLW QEIGGQPWPK ADESLLVDDT VTIAVQINGK LRTTIKVAIN 800
    LPQEELKKIA IDSVSSKIDQ SKVRTVYAVP NKIVNIVI 838
    Length:838
    Mass (Da):95,661
    Last modified:July 5, 2004 - v1
    Checksum:i81D296221BF255A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017196 Genomic DNA. Translation: AAS13823.1.
    RefSeqiNP_965889.1. NC_002978.6.
    WP_010962340.1. NC_002978.6.

    Genome annotation databases

    EnsemblBacteriaiAAS13823; AAS13823; WD_0060.
    GeneIDi2738664.
    KEGGiwol:WD0060.
    PATRICi24028685. VBIWolEnd21207_0058.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017196 Genomic DNA. Translation: AAS13823.1 .
    RefSeqi NP_965889.1. NC_002978.6.
    WP_010962340.1. NC_002978.6.

    3D structure databases

    ProteinModelPortali Q73IT7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 163164.WD0060.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS13823 ; AAS13823 ; WD_0060 .
    GeneIDi 2738664.
    KEGGi wol:WD0060.
    PATRICi 24028685. VBIWolEnd21207_0058.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci WEND163164:GJ8W-60-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSYL_WOLPM
    AccessioniPrimary (citable) accession number: Q73IT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3