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Q73IT7

- SYL_WOLPM

UniProt

Q73IT7 - SYL_WOLPM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia pipientis wMel
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei614 – 6141ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciWEND163164:GJ8W-60-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:WD_0060
OrganismiWolbachia pipientis wMel
Taxonomic identifieri163164 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000008215: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 838838Leucine--tRNA ligasePRO_0000152118Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi163164.WD0060.

Structurei

3D structure databases

ProteinModelPortaliQ73IT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi611 – 6155"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73IT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYDFKSVEK FYQDKWDFSV SKSGKQEKCY VLEMFPYPSG KIHMGHLRNY
60 70 80 90 100
AIGDVIARYK RANGFEVLHP IGWDAFGLPA ENAARDNNIS PETWTKENID
110 120 130 140 150
NMRTQLKSIG LSYNWERELS TCEPDYYKHE QKFFLDFLKH GLAYRKESWV
160 170 180 190 200
NWDPVDQTVL ANEQVVDGKG WRSGAVVEKR KLSQWFLKIT DFAEDLLKCL
210 220 230 240 250
QSLKNWPEKV KTMQERWIGK SEGATIEFEV VGLNKKLKVF TTYPHTLFGA
260 270 280 290 300
SFCAVAAEHP IVQDLKNGSS VVIPVLDTGI QEIKSKREND EKIGVYTGLN
310 320 330 340 350
VKHPFLDKEL PLYIANFVLM EYGEGAIFGC PAHDQRDFEF AQKYNLPIIP
360 370 380 390 400
VISSAHLGVI PARDQNSYNG SQCQATQMTK EAYTGDGTMF NSEFLNGLMV
410 420 430 440 450
SEAKEAIVKK FEEKKIGKKT INYRLHDWGV SRQRYWGCPI PIIYCKDCGT
460 470 480 490 500
VPVPEKDLPV VLPIDVEFTS GGNPLDKHPT WKFVDCPKCG KQAERETDTF
510 520 530 540 550
DTFFESSWYF AAFCSEDKSI DKDACNRFMP VDYYIGGIEH AILHLLYSRF
560 570 580 590 600
FCRALTKCGY FDIKEPFSTL ITQGMVCHAT YKDENGKWLF PAEAKELIAR
610 620 630 640 650
GAKVQVGKVE KMSKSKKNTV DPNFIIEKYG ADTARLFVLS DTPPEKDMEW
660 670 680 690 700
SDDGVEGCSR YVNKLWRMVM QLRPVNIHYD NENVTGGLLE YRKKIHKLLH
710 720 730 740 750
GLTDDLENCR LNCVVAKFRE MTNLIAEIDV KTGKSLIDEG ICILIRVIEP
760 770 780 790 800
FIPHLAESLW QEIGGQPWPK ADESLLVDDT VTIAVQINGK LRTTIKVAIN
810 820 830
LPQEELKKIA IDSVSSKIDQ SKVRTVYAVP NKIVNIVI
Length:838
Mass (Da):95,661
Last modified:July 5, 2004 - v1
Checksum:i81D296221BF255A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017196 Genomic DNA. Translation: AAS13823.1.
RefSeqiNP_965889.1. NC_002978.6.
WP_010962340.1. NC_002978.6.

Genome annotation databases

EnsemblBacteriaiAAS13823; AAS13823; WD_0060.
GeneIDi2738664.
KEGGiwol:WD0060.
PATRICi24028685. VBIWolEnd21207_0058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017196 Genomic DNA. Translation: AAS13823.1 .
RefSeqi NP_965889.1. NC_002978.6.
WP_010962340.1. NC_002978.6.

3D structure databases

ProteinModelPortali Q73IT7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 163164.WD0060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS13823 ; AAS13823 ; WD_0060 .
GeneIDi 2738664.
KEGGi wol:WD0060.
PATRICi 24028685. VBIWolEnd21207_0058.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci WEND163164:GJ8W-60-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYL_WOLPM
AccessioniPrimary (citable) accession number: Q73IT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3