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Q73IJ6

- DEF_WOLPM

UniProt

Q73IJ6 - DEF_WOLPM

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Protein

Peptide deformylase

Gene

def

Organism
Wolbachia pipientis wMel
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021IronUniRule annotation
Metal bindingi144 – 1441IronUniRule annotation
Active sitei145 – 1451UniRule annotation
Metal bindingi148 – 1481IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciWEND163164:GJ8W-161-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:WD_0165
OrganismiWolbachia pipientis wMel
Taxonomic identifieri163164 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000008215: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Peptide deformylasePRO_0000301124Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi163164.WD0165.

Structurei

3D structure databases

ProteinModelPortaliQ73IJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiTIMYKEG.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q73IJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILPIVIAP DERLITRASE VTDINDKIKE LVNDMFETMY DAEGLGLAAV
60 70 80 90 100
QVGVLKRIFV MDIQLETIEN EPAGYGSTGK FYMINPEITE LSDEQVILKE
110 120 130 140 150
GCLSIPEQSH EIKRPKYLTV KYKDLDNEEQ TLKASGWLAR CIQHELDHLN
160 170
GILYIRHLSK LKYDMAMKKA QKVKKHYEQ
Length:179
Mass (Da):20,555
Last modified:July 5, 2004 - v1
Checksum:i084DD7EF3EEE4476
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017196 Genomic DNA. Translation: AAS13916.1.
RefSeqiNP_965982.1. NC_002978.6.
WP_010962405.1. NC_002978.6.

Genome annotation databases

EnsemblBacteriaiAAS13916; AAS13916; WD_0165.
GeneIDi2738598.
KEGGiwol:WD0165.
PATRICi24028891. VBIWolEnd21207_0158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017196 Genomic DNA. Translation: AAS13916.1 .
RefSeqi NP_965982.1. NC_002978.6.
WP_010962405.1. NC_002978.6.

3D structure databases

ProteinModelPortali Q73IJ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 163164.WD0165.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS13916 ; AAS13916 ; WD_0165 .
GeneIDi 2738598.
KEGGi wol:WD0165.
PATRICi 24028891. VBIWolEnd21207_0158.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi TIMYKEG.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci WEND163164:GJ8W-161-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEF_WOLPM
AccessioniPrimary (citable) accession number: Q73IJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3