Q73GP1 (PYRB_WOLPM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	WD_0895

Organism

Wolbachia pipientis wMel [Complete proteome] [HAMAP]

Taxonomic identifier

163164 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113230

Sequences

	Sequence		Length	Mass (Da)
	Q73GP1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7AA0FB0EF234B680	FASTA	295	33,055
	10 20 30 40 50 60 MNKRRNLLNI SDLTVDDVEN ITKLANQYLK KEVANSHILE NKTVINLFFE DSTRTLASFE 70 80 90 100 110 120 IAAKSLGANV VTLPIRSSSI NKGEDLKDMI KTLNAMNPDY IIIRHKSSGI INTLAKYVNC 130 140 150 160 170 180 SLINAGDGSS EHPTQALADY LVISNHKKQI KDLKVVICGD ILHSRVARSN IRLLKMFGAE 190 200 210 220 230 240 INLVAPPTLI CKHFPEVDSV HYSLIEGIKD ADVIMLLRLQ KERMNNSSSE KEYFYLYGLD 250 260 270 280 290 SQKLSYAKPD AIVMHPGPIN RGIEISSDVA DCVILQQVEF GLAIRKAVLH YYRPC

References

[1]

"Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements." Wu M., Sun L.V., Vamathevan J.J., Riegler M., DeBoy R.T., Brownlie J.C., McGraw E.A., Martin W., Esser C., Ahmadinejad N., Wiegand C., Madupu R., Beanan M.J., Brinkac L.M., Daugherty S.C., Durkin A.S., Kolonay J.F., Nelson W.C. , Mohamoud Y., Lee P., Berry K.J., Young M.B., Utterback T.R., Weidman J.F., Nierman W.C., Paulsen I.T., Nelson K.E., Tettelin H., O'Neill S.L., Eisen J.A. PLoS Biol. 2:327-341(2004) [PubMed: 15024419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017196 Genomic DNA. Translation: AAS14575.1.
RefSeq	NP_966641.1. NC_002978.6.
3D structure databases
ProteinModelPortal	Q73GP1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q73GP1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBWOLT00000004569; EBWOLP00000004126; EBWOLG00000004569.
GeneID	2737722.
GenomeReviews	Gene locus WD_0895 in contig AE017196_GR.
KEGG	wol:WD0895.
PATRIC	24030376. VBIWolEnd21207_0884.
TIGR	WD_0895.
Phylogenomic databases
GeneTree	EBGT00050000031220.
HOGENOM	HBG579429.
OMA	VGIPIIN.
PhylomeDB	Q73GP1.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	WPIP955:WD_0895-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_WOLPM

Accession

Primary (citable) accession number: Q73GP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program