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Q73GN4

- PNP_WOLPM

UniProt

Q73GN4 - PNP_WOLPM

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Wolbachia pipientis wMel
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi482 – 4821MagnesiumUniRule annotation
Metal bindingi488 – 4881MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciWEND163164:GJ8W-894-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:WD_0906
OrganismiWolbachia pipientis wMel
Taxonomic identifieri163164 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
ProteomesiUP000008215: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Polyribonucleotide nucleotidyltransferasePRO_0000329935Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi163164.WD0906.

Structurei

3D structure databases

ProteinModelPortaliQ73GN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 60860KHUniRule annotationAdd
BLAST
Domaini618 – 68669S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73GN4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKIIKKSIE WGGRALSLET GKIARQAHGS VVVNYGDTSV LVTVVRKKKE
60 70 80 90 100
ESVDFLPLNV QFIAKSYAMG KIPGGFFKRE GKPSDRETLI SRVIDRSIRP
110 120 130 140 150
LFPEGFHDEI SVVCNLLTYD TVNPPEVPAL IGAVAALAIS GVPFHFTIAG
160 170 180 190 200
VMVGCDENNN YILNPSVQEM KASSLDLFLS GDENSILMVE SEVKELSEEN
210 220 230 240 250
VFNAIKFGHE HLKPVIKLIK EFADTIGNKP ESFAPIDASD ITQELEKYGK
260 270 280 290 300
DFEKAYSQTV KQERVQALEA IRENILNTLK ETGKDEKLIT YAVKNFERSL
310 320 330 340 350
VREIIRKKSV RIDGRKHDEI RQIEVEVDIL SKTHGSALFT RGNTQALVVT
360 370 380 390 400
ALGTTQDEQI VDDIEGDRRE HFMLHYNFPS FAVGETSAAR APGRREIGHG
410 420 430 440 450
KLAWKAIHPV LPDKSEFPYT IRVVSEILES DGSSSMATVC GTSLALMDTG
460 470 480 490 500
VPIKAPVAGI AMGLIKDKDE YVILSDILGD EDYLGDMDFK VAGTSEGVTA
510 520 530 540 550
LQMDMKISGI SFEIVEKSLE QAKAGRLHIL EKMNAVISEH SDDVKDHAPR
560 570 580 590 600
MLSFYIDKDK ISAAIGSKGK NIRSVCERSN AKIEIGDDGK VSVFATSGTE
610 620 630 640 650
AEIAKSMMID SITELEQGSI VDVKVVRIEK SIVELEFLNG RKGKMHISEV
660 670 680 690 700
ANEHIDSIES VLKQDDTFKA LVIDFEKGGC PKLSRRRVDQ ETGEFFEGEL
710 720 730 740 750
YNEERKDGPN DRDNYYNNSF SRKPGGSHHK RPPRPHSGFS NRNRPKFGNN

DSSSGFY
Length:757
Mass (Da):84,015
Last modified:July 5, 2004 - v1
Checksum:i5855FA395748B918
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017196 Genomic DNA. Translation: AAS14582.1.
RefSeqiNP_966648.1. NC_002978.6.
WP_010962918.1. NC_002978.6.

Genome annotation databases

EnsemblBacteriaiAAS14582; AAS14582; WD_0906.
GeneIDi2738382.
KEGGiwol:WD0906.
PATRICi24030404. VBIWolEnd21207_0898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017196 Genomic DNA. Translation: AAS14582.1 .
RefSeqi NP_966648.1. NC_002978.6.
WP_010962918.1. NC_002978.6.

3D structure databases

ProteinModelPortali Q73GN4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 163164.WD0906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS14582 ; AAS14582 ; WD_0906 .
GeneIDi 2738382.
KEGGi wol:WD0906.
PATRICi 24030404. VBIWolEnd21207_0898.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci WEND163164:GJ8W-894-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPNP_WOLPM
AccessioniPrimary (citable) accession number: Q73GN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3