psd

Functionⁱ

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).UniRule annotation

Catalytic activityⁱ

Phosphatidyl-L-serine = phosphatidylethanolamine + CO₂.UniRule annotation

Cofactorⁱ

pyruvateUniRule annotationNote: Binds 1 pyruvoyl group covalently per subunit.UniRule annotation

Pathwayⁱ: phosphatidylethanolamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylethanolamine from CDP-diacylglycerol.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

no protein annotated in this organism
Phosphatidylserine decarboxylase proenzyme (psd)

This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from CDP-diacylglycerol, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	186	Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation		1

GO - Molecular functionⁱ

phosphatidylserine decarboxylase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phosphatidylethanolamine biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Decarboxylase, Lyase
Biological process	Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
Ligand	Pyruvate

Enzyme and pathway databases

UniPathwayⁱ	UPA00558; UER00616.

UniPathwayⁱ

UPA00558; UER00616.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphatidylserine decarboxylase proenzymeUniRule annotation (EC:4.1.1.65UniRule annotation) Cleaved into the following 2 chains: Phosphatidylserine decarboxylase alpha chainUniRule annotation Phosphatidylserine decarboxylase beta chainUniRule annotation
Gene namesⁱ	Name:psdUniRule annotation Ordered Locus Names:WD_1049
Organismⁱ	Wolbachia pipientis wMel
Taxonomic identifierⁱ	163164 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia
Proteomesⁱ	UP000008215 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00664
; Peripheral membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00664

GO - Cellular componentⁱ

plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000029815	1 – 185	Phosphatidylserine decarboxylase beta chainUniRule annotationAdd BLAST		185
ChainⁱPRO_0000029816	186 – 230	Phosphatidylserine decarboxylase alpha chainUniRule annotationAdd BLAST		45

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	186	Pyruvic acid (Ser); by autocatalysisUniRule annotation		1

Post-translational modificationⁱ

Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	185 – 186	Cleavage (non-hydrolytic); by autocatalysisUniRule annotation		2

Keywords - PTMⁱ

Zymogen

Proteomic databases

PRIDEⁱ	Q73GB0.

PRIDEⁱ

Q73GB0.

Interactionⁱ

Subunit structureⁱ

Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	163164.WD1049.

STRINGⁱ

163164.WD1049.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG41071I4. Bacteria. COG0688. LUCA.
HOGENOMⁱ	HOG000229359.
KEGG Orthology (KO) More...KOⁱ	K01613.
OMAⁱ	VSIFMSP.

Family and domain databases

HAMAPⁱ	MF_00664. PS_decarb_PSD_A. 1 hit.
InterProⁱ	View protein in InterPro IPR003817. PS_Dcarbxylase. IPR033175. PSD-A.
PANTHERⁱ	PTHR35809. PTHR35809. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02666. PS_Dcarbxylase. 1 hit.
TIGRFAMsⁱ	TIGR00164. PS_decarb_rel. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q73GB0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCFGLPNINR EGYSFIVVSF IVTCIAFSIS WGFGVTCLFP TLLCTYFFRD 
        60         70         80         90        100
PARAVPNNKN LILSPADGVI SKIEEVNYPL SAENGEEKKF TLVSIFLSVL 
       110        120        130        140        150
NVHVNRIPIS GTIKEMSYKK GKFVSAMSNR SSNENEKQVI VIEYEKGKEI 
       160        170        180        190        200
IVEQIAGLIA RRIVCNLGIS QNVKAGERFG IIRFGSRVNI YVPADTEVRV 
       210        220        230
SEGQTVIGGE TIIANLNKEN VQEKLTFDVI

Length:230

Mass (Da):25,537

Last modified:July 5, 2004 - v1

Checksum:ⁱBDA9E9E86159BA02

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017196 Genomic DNA. Translation: AAS14706.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_007548750.1. NC_002978.6.

Genome annotation databases

EnsemblBacteriaⁱ	AAS14706; AAS14706; WD_1049.
GeneIDⁱ	29555573.
KEGGⁱ	wol:WD_1049.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q73GB0	C0R4E0 A0A1D8MLK6 M9WWN7 Q4ECE0 A0A098ATH1 A0A1V2N550	Wolbachia sp. subsp. Drosophila simulans (strain wRi) Wolbachia endosymbiont of Drosophila incompta Wolbachia endosymbiont of Drosophila simulans wHa Wolbachia endosymbiont of Drosophila ananassae Wolbachia endosymbiont of Drosophila simulans wAu Wolbachia pipientis wVitA	230	UniRef100_Q73GB0	Cluster: Phosphatidylserine decarboxylase proenzyme	7

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q73GB0	C0R4E0 A0A1D8MLK6 M9WWN7 Q4ECE0 A0A098ATH1 A0A1V2N550 A0A059IVM3 A0A2A4IJ29 C0F8V0 A0A178GS46 +8	Wolbachia sp. subsp. Drosophila simulans (strain wRi) Wolbachia endosymbiont of Drosophila incompta Wolbachia endosymbiont of Drosophila simulans wHa Wolbachia endosymbiont of Drosophila ananassae Wolbachia endosymbiont of Drosophila simulans wAu Wolbachia pipientis wVitA Wolbachia endosymbiont of Glossina morsitans morsitans Wolbachia pipientis Wolbachia endosymbiont of Muscidifurax uniraptor Wolbachia endosymbiont of Dactylopius coccus And more	230	UniRef90_Q73GB0	Cluster: Phosphatidylserine decarboxylase proenzyme	19

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q73GB0	Q5PB25 B9KI98 D1ASB7 C0F8V0 UPI0007EEA40F A0A059IVM3 A0A178GS46 C0R4E0 A0A1D8MLK6 M9WWN7 +31	Anaplasma marginale (strain St. Maries) Anaplasma marginale (strain Florida) Anaplasma centrale (strain Israel) (Anaplasma marginale subsp. centrale (strain Israel)) Wolbachia endosymbiont of Muscidifurax uniraptor Wolbachia Wolbachia endosymbiont of Glossina morsitans morsitans Wolbachia endosymbiont of Dactylopius coccus Wolbachia sp. subsp. Drosophila simulans (strain wRi) Wolbachia endosymbiont of Drosophila incompta Wolbachia endosymbiont of Drosophila simulans wHa And more	227	UniRef50_Q5PB25	Cluster: Phosphatidylserine decarboxylase proenzyme	42

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017196 Genomic DNA. Translation: AAS14706.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_007548750.1. NC_002978.6.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	163164.WD1049.

STRINGⁱ

163164.WD1049.

Proteomic databases

PRIDEⁱ	Q73GB0.

PRIDEⁱ

Q73GB0.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAS14706; AAS14706; WD_1049.
GeneIDⁱ	29555573.
KEGGⁱ	wol:WD_1049.

Phylogenomic databases

eggNOGⁱ	ENOG41071I4. Bacteria. COG0688. LUCA.
HOGENOMⁱ	HOG000229359.
KEGG Orthology (KO) More...KOⁱ	K01613.
OMAⁱ	VSIFMSP.

Enzyme and pathway databases

UniPathwayⁱ	UPA00558; UER00616.

UniPathwayⁱ

UPA00558; UER00616.

Family and domain databases

HAMAPⁱ	MF_00664. PS_decarb_PSD_A. 1 hit.
InterProⁱ	View protein in InterPro IPR003817. PS_Dcarbxylase. IPR033175. PSD-A.
PANTHERⁱ	PTHR35809. PTHR35809. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02666. PS_Dcarbxylase. 1 hit.
TIGRFAMsⁱ	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PSD_WOLPM
Accessionⁱ	Q73GB0Primary (citable) accession number: Q73GB0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
	Last sequence update:	July 5, 2004
	Last modified:	December 20, 2017
	This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q73GB0 (PSD_WOLPM)

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Phosphatidylserine decarboxylase proenzyme

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylethanolamine biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: phosphatidylethanolamine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ