Q73G84 (SURE_WOLPM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	WD_1077

Organism

Wolbachia pipientis wMel [Complete proteome] [HAMAP]

Taxonomic identifier

163164 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235667
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	40	1	Divalent metal cation By similarity
	Metal binding	94	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73G84 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 434AACC2CF13CD5B	FASTA	250	27,227
	10 20 30 40 50 60 MIILITNDDG FGSEGIKLLK EVARNFASEI WIVAPDTDRS GAARSLDYPV KQSIGIKQHS 70 80 90 100 110 120 EREFSVSGTP ADCVIIALNK VMNKKPDLIL SGVNIGSNVG DDICYSGTIG AVMEGAARSI 130 140 150 160 170 180 PSIALSQVYH DKIDWHNTKV FAPKVIAKLV KVGWPKNIVM SVNFPAKEKV KGVEFAEQGE 190 200 210 220 230 240 YNIDGDLTFT ENSNGSFSLN WSREHSGSGS INKIKEGFIT ITPVKLDFTD YDTLNTMKNS 250 CADEFSSIAD

References

[1]

"Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements." Wu M., Sun L.V., Vamathevan J.J., Riegler M., DeBoy R.T., Brownlie J.C., McGraw E.A., Martin W., Esser C., Ahmadinejad N., Wiegand C., Madupu R., Beanan M.J., Brinkac L.M., Daugherty S.C., Durkin A.S., Kolonay J.F., Nelson W.C. , Mohamoud Y., Lee P., Berry K.J., Young M.B., Utterback T.R., Weidman J.F., Nierman W.C., Paulsen I.T., Nelson K.E., Tettelin H., O'Neill S.L., Eisen J.A. PLoS Biol. 2:327-341(2004) [PubMed: 15024419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017196 Genomic DNA. Translation: AAS14732.1.
RefSeq	NP_966798.1. NC_002978.6.
3D structure databases
ProteinModelPortal	Q73G84.
ModBase	Search...
Protein-protein interaction databases
STRING	Q73G84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBWOLT00000004277; EBWOLP00000003834; EBWOLG00000004277.
GeneID	2737827.
GenomeReviews	Gene locus WD_1077 in contig AE017196_GR.
KEGG	wol:WD1077.
PATRIC	24030758. VBIWolEnd21207_1071.
TIGR	WD_1077.
Phylogenomic databases
GeneTree	EBGT00050000030883.
HOGENOM	HBG600532.
OMA	MEGAARS.
PhylomeDB	Q73G84.
ProtClustDB	CLSK740019.
Enzyme and pathway databases
BioCyc	WPIP955:WD_1077-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_WOLPM

Accession

Primary (citable) accession number: Q73G84

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program