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Q73FY6 (HEMH_WOLPM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:WD_1186
OrganismWolbachia pipientis wMel [Complete proteome] [HAMAP]
Taxonomic identifier163164 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachieae › Wolbachia

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Ferrochelatase HAMAP MF_00323
PRO_0000175227

Sites

Metal binding1931Iron By similarity
Metal binding2731Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73FY6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: FD28486965251112

FASTA31536,324
        10         20         30         40         50         60 
MKKAVILFNL GGPDSLNAVR PFLFNLFYDR RIINLPNPFR FLLAKFISAK RENTARKIYE 

        70         80         90        100        110        120 
EIGGKSPILE NTKMQANASE LKLNENRNHV HKVFICMRYW RPFADEVIES VKQFDPDEVI 

       130        140        150        160        170        180 
LLPLYPQYST TTTLSSIENW QKNAKRYGLK CNTKMIHRYY DNQDFIEAHT NLIAKYYKLA 

       190        200        210        220        230        240 
RKIGKPRVLF SAHSLPLSII KKGDPYASQV ERSVELIVEK LAINNLDWSI CYQSKIGPVK 

       250        260        270        280        290        300 
WLEPSTESEL LRAKADGVPV VLSPISFVSE HSETLVELDI EYKAIIKDGY YFRVPTLSTD 

       310 
PLFIKCLADL CINLP

« Hide

References

[1]"Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements."
Wu M., Sun L.V., Vamathevan J.J., Riegler M., DeBoy R.T., Brownlie J.C., McGraw E.A., Martin W., Esser C., Ahmadinejad N., Wiegand C., Madupu R., Beanan M.J., Brinkac L.M., Daugherty S.C., Durkin A.S., Kolonay J.F., Nelson W.C. expand/collapse author list , Mohamoud Y., Lee P., Berry K.J., Young M.B., Utterback T.R., Weidman J.F., Nierman W.C., Paulsen I.T., Nelson K.E., Tettelin H., O'Neill S.L., Eisen J.A.
PLoS Biol. 2:327-341(2004) [PubMed: 15024419] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017196 Genomic DNA. Translation: AAS14832.1.
RefSeqNP_966898.1. NC_002978.6.

3D structure databases

ProteinModelPortalQ73FY6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ73FY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBWOLT00000003945; EBWOLP00000003502; EBWOLG00000003945.
GeneID2738698.
GenomeReviewsGene locus WD_1186 in contig AE017196_GR.
KEGGwol:WD1186.
PATRIC24030961. VBIWolEnd21207_1170.
TIGRWD_1186.

Phylogenomic databases

GeneTreeEBGT00050000031382.
HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBQ73FY6.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycWPIP955:WD_1186-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_WOLPM
AccessionPrimary (citable) accession number: Q73FY6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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