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Protein

Protein-arginine kinase

Gene

mcsB

Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-arginine = ADP + a [protein]-N(omega)-phospho-L-arginine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92ATPUniRule annotation1
Binding sitei125ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 31ATPUniRule annotation5
Nucleotide bindingi176 – 180ATPUniRule annotation5
Nucleotide bindingi207 – 212ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine kinaseUniRule annotation (EC:2.7.14.1UniRule annotation)
Gene namesi
Name:mcsBUniRule annotation
Ordered Locus Names:BCE_0080
OrganismiBacillus cereus (strain ATCC 10987 / NRS 248)
Taxonomic identifieri222523 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002527 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002120121 – 354Protein-arginine kinaseAdd BLAST354

Structurei

3D structure databases

ProteinModelPortaliQ73FC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 254Phosphagen kinase C-terminalUniRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.UniRule annotation
Contains 1 phosphagen kinase C-terminal domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000082112.
KOiK19405.
OMAiNIRFTEK.

Family and domain databases

CDDicd07930. bacterial_phosphagen_kinase. 1 hit.
Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase. 1 hit.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73FC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDKIMNEA ISPWMKGDGP DSDIVLSSRI RLARNFKKYQ FSTMQNEEEA
60 70 80 90 100
KLIQELFKKE FINKTVEPFG EFELLKMNEL TPLQRRVLVE KHLISPNLAG
110 120 130 140 150
TEYGACLLSE SEHISVMLNE EDHIRIQCLF SGLQLSEALQ SANQIDNWIE
160 170 180 190 200
KEVEYAFDES LGYITSCPTN VGTGLRASVM IHLPGLVLTK RISRIIQVIQ
210 220 230 240 250
KLGLVVRGIY GEGSEALGNI FQVSNQMTLG KSEEDIIADL KSVIQQIIQQ
260 270 280 290 300
EKMARELIVQ NSSIELEDKV YRSYGILANS RLIQSAEAAN CLSDLRLGID
310 320 330 340 350
LGYIKGISRN ILTELMVLTQ PGILQQYAGG PLGPEERDYR RATLIRERLR

IEKN
Length:354
Mass (Da):39,990
Last modified:July 5, 2004 - v1
Checksum:i131F4EA9B506519F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA. Translation: AAS39016.1.
RefSeqiWP_000050822.1. NC_003909.8.

Genome annotation databases

EnsemblBacteriaiAAS39016; AAS39016; BCE_0080.
KEGGibca:BCE_0080.
PATRICi18848984. VBIBacCer118379_0076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA. Translation: AAS39016.1.
RefSeqiWP_000050822.1. NC_003909.8.

3D structure databases

ProteinModelPortaliQ73FC6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS39016; AAS39016; BCE_0080.
KEGGibca:BCE_0080.
PATRICi18848984. VBIBacCer118379_0076.

Phylogenomic databases

HOGENOMiHOG000082112.
KOiK19405.
OMAiNIRFTEK.

Family and domain databases

CDDicd07930. bacterial_phosphagen_kinase. 1 hit.
Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase. 1 hit.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCSB_BACC1
AccessioniPrimary (citable) accession number: Q73FC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.