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Q73F49

- GLMS_BACC1

UniProt

Q73F49 - GLMS_BACC1

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, BCE_0158
Organism
Bacillus cereus (strain ATCC 10987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei595 – 5951For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:BCE_0158
OrganismiBacillus cereus (strain ATCC 10987)
Taxonomic identifieri222523 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002527: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 600599Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135294Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi222523.BCE_0158.

Structurei

3D structure databases

ProteinModelPortaliQ73F49.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2Add
BLAST
Domaini283 – 422140SIS 1Add
BLAST
Domaini452 – 590139SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSVFETQT.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q73F49-1 [UniParc]FASTAAdd to Basket

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MCGIVGFIGE QDAKEILLKG LEKLEYRGYD SAGIAVQAEN GVVVYKEKGR    50
IAKLREIVDE NVATSVGIGH TRWATHGVPS KVNAHPHQST SKRFTLVHNG 100
VIENYELVKK EYLQDVTFVS ETDTEVIVQL MEQQVSTGLS VEEAFRNTLS 150
LLHGSYAIGL LDAENPNMIY VAKNKSPLLV GVGDNFNVVA SDAMAMLQVT 200
DQFIELMDKE IVIVTKESIT IKNLQGETIE RAPFTAELDA SDIEKGTYPH 250
FMLKEIDEQP LVIRNIIQKY QDENGEIELD QDIRNAILDS DRIYIIACGT 300
SYHAGLVGKQ FIEKFAKMPV EVHVASEFSY NMPLLTERPF FIYISQSGET 350
ADSRAVLVQT NEMGHKALTI TNVPGSTLSR EADYTLPLYA GPEIAVASTK 400
AYTAQLAVLS ILAADIAKAK GEVLGFDLTH ELGLVANAMV QLCDQKEEMD 450
ALAKQFLATT RNCFFIGRSV DFYVGLEGAL KLKEISYIQA EGFAGGELKH 500
GTIALIENGT PVIALATQEH VNLGIRGNVK EVVARGANPC IISMKGLEME 550
GDSFVLPAVH EALAPLVAVI PLQLISYYAA LHRECDVDKP RNLAKSVTVE 600
Length:600
Mass (Da):65,750
Last modified:January 23, 2007 - v3
Checksum:iCF9D5EDB164B7892
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017194 Genomic DNA. Translation: AAS39094.1.
RefSeqiNP_976486.1. NC_003909.8.

Genome annotation databases

EnsemblBacteriaiAAS39094; AAS39094; BCE_0158.
GeneIDi2748273.
KEGGibca:BCE_0158.
PATRICi18849162. VBIBacCer118379_0153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017194 Genomic DNA. Translation: AAS39094.1 .
RefSeqi NP_976486.1. NC_003909.8.

3D structure databases

ProteinModelPortali Q73F49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 222523.BCE_0158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS39094 ; AAS39094 ; BCE_0158 .
GeneIDi 2748273.
KEGGi bca:BCE_0158.
PATRICi 18849162. VBIBacCer118379_0153.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi SVFETQT.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1."
    Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.
    Nucleic Acids Res. 32:977-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10987.

Entry informationi

Entry nameiGLMS_BACC1
AccessioniPrimary (citable) accession number: Q73F49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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