Q73EN8 (PUR7_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	BCE_0320

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000018665

Sequences

	Sequence		Length	Mass (Da)
	Q73EN8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F67CB3AA4D8490A5	FASTA	239	27,236
	10 20 30 40 50 60 MQKLELLYEG KAKRIYRTES ADMVWVEYKD SATAFNGEKK ETITGKGRLN NEITTLLFRK 70 80 90 100 110 120 LQEVGIKTHF VEKLSETEQL VKKVSIIPLE VVTRNVIAGS LSKRLGMEEG TVLAEPIVEF 130 140 150 160 170 180 YFKDDDLGDP LVTEDHIRVL NVASPEQVSV LRDMALQINQ VLIDHFASCR VRLVDFKLEF 190 200 210 220 230 GVTDEGEIIL ADEISPDTCR LWDETSNEKF DKDVFRRDLG NLTDAYEEIL KRLGGISHV

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS39256.1.
RefSeq	NP_976648.1. NC_003909.8.
3D structure databases
HSSP	HSSP built from PDB template 2GQR based on UniProtKB P0A7D7.
ProteinModelPortal	Q73EN8.
SMR	Q73EN8. Positions 3-235.
ModBase	Search...
Protein-protein interaction databases
STRING	Q73EN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000024828; EBBACP00000024178; EBBACG00000024819.
GeneID	2751847.
GenomeReviews	Gene locus BCE_0320 in contig AE017194_GR.
KEGG	bca:BCE_0320.
PATRIC	18849520. VBIBacCer118379_0307.
TIGR	BCE_0320.
Phylogenomic databases
eggNOG	COG0152.
GeneTree	EBGT00050000000820.
HOGENOM	HBG306070.
OMA	YKDDALG.
ProtClustDB	PRK09362.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_0320-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_BACC1

Accession

Primary (citable) accession number: Q73EN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program