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Q73E86 (OTCC_BACC1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
Ordered Locus Names:BCE_0473
OrganismBacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]
Taxonomic identifier222523 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000112877

Regions

Region60 – 645Carbamoyl phosphate binding By similarity
Region270 – 2734Ornithine binding By similarity

Sites

Binding site1111Carbamoyl phosphate By similarity
Binding site1381Carbamoyl phosphate By similarity
Site351Important for structural integrity By similarity
Site1511Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73E86 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D2CBD4944C6575D1

FASTA33237,549
        10         20         30         40         50         60 
MLMTRPNLKG RSFLAEKDFT QEELLYFLDL AAELKEKKKN GIPHHYLEGK NVALLFEKTS 

        70         80         90        100        110        120 
TRTRCAFTVA CTDLGANPEY LGKSDIQLGK KESVEDTAKV LGRMFDGIEF RGFNHETVES 

       130        140        150        160        170        180 
LAQNSGVPVW NGLTDMWHPT QTLADLLTIR EHVGKLKNVK LVYVGDGRNN VANSLLVGGA 

       190        200        210        220        230        240 
IVGMDVRICT PETLWPAQEV IDLAKKYNEQ VMITSNVEEA VANADVIYTD VWVSMGEEEK 

       250        260        270        280        290        300 
FAERVKLLKP YQVNMKMIKE TGNENVIFLH CLPAFHDVET MYGEEVYEKY GLKEMEVTDE 

       310        320        330 
VFRSKHSKVF DQAENRMHTI KAVMAATLGN ME

« Hide

References

[1]"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1."
Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.
Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017194 Genomic DNA. Translation: AAS39408.1.
RefSeqNP_976800.1. NC_003909.8.

3D structure databases

ProteinModelPortalQ73E86.
SMRQ73E86. Positions 7-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ73E86.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000029073; EBBACP00000028423; EBBACG00000029064.
GeneID2748291.
GenomeReviewsGene locus BCE_0473 in contig AE017194_GR.
KEGGbca:BCE_0473.
NMPDRfig|222523.1.peg.472.
PATRIC18849800. VBIBacCer118379_0447.
TIGRBCE_0473.

Phylogenomic databases

eggNOGCOG0078.
GeneTreeEBGT00050000002562.
HOGENOMHBG579429.
OMAVRICTPE.
ProtClustDBPRK02102.

Enzyme and pathway databases

BioCycBCER405917:BCE_0473-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
KOK00611.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTCC_BACC1
AccessionPrimary (citable) accession number: Q73E86
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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