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Q73DM2 (Q73DM2_BACC1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase 1 HAMAP MF_01208
Short name=OPRT 1 HAMAP MF_01208
Short name=OPRTase 1 HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE1 HAMAP MF_01208
Ordered Locus Names:BCE_0690
OrganismBacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP] EMBL AAS39623.1
Taxonomic identifier222523 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region114 – 12295-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site2315-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site8815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site8915-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1181Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
Q73DM2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F020EB559AA985F9

FASTA18019,822
        10         20         30         40         50         60 
MEKWELAKEI YNTSRLTGTF KLRSGQVSNQ YFDKYLFESN PVLLVEIAKQ LKELIPPETE 

        70         80         90        100        110        120 
VLAGLEMGGI PVATALSLQT GIPVVFVRKE AKKYGTCKLA EGVDIAGKNV CVVEDVITTG 

       130        140        150        160        170        180 
GQILLSTKDL RGLGAKVHHV LGVIERTKEG KENLLEDGLQ LHSLFTMDEL IEGEKQHAKS

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References

[1]"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1."
Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.
Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017194 Genomic DNA. Translation: AAS39623.1.
RefSeqNP_977015.1. NC_003909.8.

3D structure databases

ProteinModelPortalQ73DM2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ73DM2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000027103; EBBACP00000026453; EBBACG00000027094.
GeneID2752600.
GenomeReviewsGene locus BCE_0690 in contig AE017194_GR.
KEGGbca:BCE_0690.
NMPDRfig|222523.1.peg.687.
PATRIC18850250. VBIBacCer118379_0653.
TIGRBCE_0690.

Phylogenomic databases

eggNOGCOG0461.
GeneTreeEBGT00050000002725.
HOGENOMHBG404341.
OMAQTCLVIN.
ProtClustDBCLSK925627.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ73DM2_BACC1
AccessionPrimary (citable) accession number: Q73DM2
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info