Reviewed, UniProtKB/Swiss-Prot Q73C98 (HEMH1_BACC1)

Names and origin

Protein names

Recommended name:
    Ferrochelatase 1
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase 1
    Heme synthetase 1

Gene names

Name:	hemH1
Ordered Locus Names:	BCE_1168

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Ferrochelatase 1 HAMAP MF_00323		PRO_0000175104
Sites
	Metal binding	182	1	Iron By similarity
	Metal binding	263	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73C98-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 25B6D263536C2844	FASTA	311	35,339
	10 20 30 40 50 60 MKKKIGLLVM AYGTPYKEED IERYYTHIRR GRKPSPEMLE DLTERYRAIG GISPLATITL 70 80 90 100 110 120 EQAKKLEKRL NEVQDEVEYH MYLGLKHIEP FIEDAVKDMH NDGIQDAIAL VLAPHYSTFS 130 140 150 160 170 180 VKSYVGRAQE EAEKLGNLTI HGIDSWYKEP KFIQYWVDAV KGIYNGMSDA EREKAVLIVS 190 200 210 220 230 240 AHSLPEKIIA MGDPYPEQLH ETADYIARGA EVANYAVGWQ SAGNTPDPWI GPDVQDLTRE 250 260 270 280 290 300 LNEKHGYTSF VYAPVGFVAE HLEVLYDNDF ECKVVTDEIG AKYYRPEMPN ASDAFIDCLT 310 DVVLKKKESV L

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017194 Genomic DNA. Translation: AAS40098.1.
RefSeq	NP_977490.1.
3D structure databases
HSSP	HSSP built from PDB template 1AK1 based on UniProtKB P32396.
SMR	Q73C98. Positions 1-311.
ModBase	Search...
Protein-protein interaction databases
STRING	Q73C98.
Genome annotation databases
GeneID	2752410.
GenomeReviews	Gene locus BCE_1168 in contig AE017194_GR.
KEGG	bca:BCE_1168.
NMPDR	fig|222523.1.peg.1162.
TIGR	BCE_1168.
Phylogenomic databases
HOGENOM	Q73C98.
OMA	NEMIVSH.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH1_BACC1

Accession

Primary (citable) accession number: Q73C98

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)