Q73C08 (HEMH2_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrochelatase 2
EC=4.99.1.1

Alternative name(s):
Heme synthase 2
Protoheme ferro-lyase 2

Gene names

Name:	hemH2
Ordered Locus Names:	BCE_1260

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Ferrochelatase 2 HAMAP MF_00323		PRO_0000175105
Sites
	Metal binding	181	1	Iron By similarity
	Metal binding	262	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73C08 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9C92A211E0D11C7F	FASTA	319	36,335
	10 20 30 40 50 60 MAKKKIGLLV MAYGTPESLE DVEAYYTHIR HGRKPSEEAL QDLIGRYKAI GGISPLAKIT 70 80 90 100 110 120 KEQAHKLTDS MNNIFTEYEF NCYLGLKHIA PFIEDAVEEM KRDGIEQAIS IVLAPHYSTF 130 140 150 160 170 180 SIKAYNDRAI RLSEEIGGPV IEPIEQWYDE PKFISYWADQ IKETFTKIED KEKAVVIFSA 190 200 210 220 230 240 HSLPEKIIAA GDPYVKQLQH TADLIAAAAN IQNYTIGWQS AGNTPDPWIG PDVQDLTRDL 250 260 270 280 290 300 FEEHRYESFI YCPVGFVAEH LEVLYDNDYE CRVVTDEINA AYFRPNMPNS QSIFIDCLTE 310 IVSKKMKEVV DKDLVLNNN

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS40189.1.
RefSeq	NP_977581.1. NC_003909.8.
3D structure databases
ProteinModelPortal	Q73C08.
SMR	Q73C08. Positions 3-310.
ModBase	Search...
Protein-protein interaction databases
STRING	Q73C08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000026174; EBBACP00000025524; EBBACG00000026165.
GeneID	2747300.
GenomeReviews	Gene locus BCE_1260 in contig AE017194_GR.
KEGG	bca:BCE_1260.
NMPDR	fig|222523.1.peg.1253.
PATRIC	18851384. VBIBacCer118379_1197.
TIGR	BCE_1260.
Phylogenomic databases
eggNOG	COG0276.
GeneTree	EBGT00050000002085.
HOGENOM	HBG697135.
OMA	LEPDIVD.
ProtClustDB	PRK12435.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_1260-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH2_BACC1

Accession

Primary (citable) accession number: Q73C08

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program