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Q73AX9 (AROC1_BACC1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase 1
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase 1
Gene names
Name:aroC1
Ordered Locus Names:BCE_1643
OrganismBacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]
Taxonomic identifier222523 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Chorismate synthase 1 HAMAP MF_00300
PRO_0000140541

Sequences

Sequence LengthMass (Da)Tools
Q73AX9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E315D320A0266A6D

FASTA39042,425
        10         20         30         40         50         60 
MRYITAGESH GPQLTTIIEG VPAGLPLVAD DINEELARRQ KGYGRGRRMQ IETDQVQIVS 

        70         80         90        100        110        120 
GVRHGETLGS PIALVVENRD FAHWTKIMGA EPLTEQEEKE MKRKVTKPRP GHADLNGAIK 

       130        140        150        160        170        180 
YGHRDMRNVL ERSSARETTV RVAAGAVAKK VLAELGIAVA GHVIEIGGVQ AKETTYRSIE 

       190        200        210        220        230        240 
ELKSITEASP VRCLDEEAGN QMIKAIDDAK SNGDSIGGIV EVIVEGMPIG VGSYVHYDRK 

       250        260        270        280        290        300 
LDAKLAAAMM SINAFKGVEI GIGFEAAHRP GSEVHDEIVW NEEHGYTRRT NNAGGLEGGM 

       310        320        330        340        350        360 
TTGMPIVVRG VMKPIPTLYK PLQSVDIDTK EPFTASIERS DSCAVPAASV VAEAVVAWEL 

       370        380        390 
ATAVIEQFGL DRMDLIRENI ERHNEYARGF

« Hide

References

[1]"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1."
Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.
Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017194 Genomic DNA. Translation: AAS40572.1.
RefSeqNP_977964.1. NC_003909.8.

3D structure databases

ProteinModelPortalQ73AX9.
SMRQ73AX9. Positions 1-390.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ73AX9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000029724; EBBACP00000029074; EBBACG00000029715.
GeneID2747876.
GenomeReviewsGene locus BCE_1643 in contig AE017194_GR.
KEGGbca:BCE_1643.
NMPDRfig|222523.1.peg.1636.
PATRIC18852115. VBIBacCer118379_1561.
TIGRBCE_1643.

Phylogenomic databases

eggNOGCOG0082.
GeneTreeEBGT00050000002373.
HOGENOMHBG292336.
OMAMLRWLTA.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycBCER405917:BCE_1643-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC1_BACC1
AccessionPrimary (citable) accession number: Q73AX9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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