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Q73AX8 (AROB_BACC1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BCE_1644
OrganismBacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]
Taxonomic identifier222523 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3613613-dehydroquinate synthase HAMAP MF_00110
PRO_0000231063

Sequences

Sequence LengthMass (Da)Tools
Q73AX8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C6DD017EECD08589

FASTA36140,060
        10         20         30         40         50         60 
MGNIHIQTKS KEYDVYVGKE SLSHLTTIVQ NMKPSVSNIM IISDEAVASL HLQMVVDALQ 

        70         80         90        100        110        120 
IEKKVFSFVV PSGEKEKSFE NFYAAHTSAL ENKLDRNSLI IALGGGMIGD LAGFVAASFM 

       130        140        150        160        170        180 
RGIRFVQVPT TLLAHDSAVG GKVAINHPLG KNMIGAFHQP EAVVYHTPFL QSLPEKEWRS 

       190        200        210        220        230        240 
GYAEVIKHAL IGDVKLYHWL KEEVQTLADL RDEKLIHILT KAIPVKANIV AQDETEKGVR 

       250        260        270        280        290        300 
AHLNFGHTLG HALEKELGYG NITHGDGVAV GMLFAIFLSE QVYKVNLAYE EMKQWFLKYG 

       310        320        330        340        350        360 
YPKMPSDLNV ERLVGLMKQD KKANAGAIHM VLMQEYGVVN VVSIPDETVH IALEAFQKDM 


V

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References

[1]"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1."
Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.
Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017194 Genomic DNA. Translation: AAS40573.1.
RefSeqNP_977965.1. NC_003909.8.

3D structure databases

ProteinModelPortalQ73AX8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ73AX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000028602; EBBACP00000027952; EBBACG00000028593.
GeneID2750267.
GenomeReviewsGene locus BCE_1644 in contig AE017194_GR.
KEGGbca:BCE_1644.
NMPDRfig|222523.1.peg.1637.
PATRIC18852117. VBIBacCer118379_1562.
TIGRBCE_1644.

Phylogenomic databases

eggNOGCOG0337.
GeneTreeEBGT00050000002325.
HOGENOMHBG632303.
OMAGTFTQPD.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBCER405917:BCE_1644-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BACC1
AccessionPrimary (citable) accession number: Q73AX8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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