Reviewed, UniProtKB/Swiss-Prot Q73AW1 (DAPB_BACC1)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	BCE_1661

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Dihydrodipicolinate reductase		PRO_0000228321

Sequences

	Sequence		Length	Mass (Da)
	Q73AW1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4ACFF04A1302DE94	FASTA	266	29,263
	10 20 30 40 50 60 MKEIKVIIAG PRGRMGHEAV LLMERTEHFN LVAAVDYKHG GEKISDLPGM PALDTPIYAD 70 80 90 100 110 120 LHTCLEEVEA DVLLDLTTPE VGKQHVTLAV ERGLRSVIGT TGFTEEELKQ LTETAKEKAV 130 140 150 160 170 180 GTIIAPNFAI GAVLMMKFSQ MAAKYFQDVE VIELHHDQKL DAPSGTAVKT VELIRQNRES 190 200 210 220 230 240 KQQGHPNEVE QLKGARGANV DGIHIHSVRL PGLIAHQEVM FGGDGQMLTV RHDSFNRASF 250 260 MSGVKLSIET VMNLDHLVYG LENIID

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017194 Genomic DNA. Translation: AAS40590.1.
RefSeq	NP_977982.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2747880.
GenomeReviews	Gene locus BCE_1661 in contig AE017194_GR.
KEGG	bca:BCE_1661.
NMPDR	fig|222523.1.peg.1654.
TIGR	BCE_1661.
Phylogenomic databases
HOGENOM	Q73AW1.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. [Graphical view]
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BACC1

Accession

Primary (citable) accession number: Q73AW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)