Q739I5 (ACDH_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Ordered Locus Names:

BCE_2156

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus cereus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Acetaldehyde dehydrogenase HAMAP-Rule MF_01657		PRO_0000387624
Regions
	Nucleotide binding	11 – 14	4	NAD By similarity
	Nucleotide binding	157 – 165	9	NAD By similarity
Sites
	Active site	126	1	Acyl-thioester intermediate By similarity
	Binding site	267	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q739I5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6E914F2D2399564C	FASTA	299	32,422
	10 20 30 40 50 60 MKKVKAAIIG SGNIGTDLMY KLKNSKVIEL NAMIGIDSES DGLKRAKEAG YEVFDNGIQA 70 80 90 100 110 120 IIDNPSLADI VFDATSAKAH SYHAKILEEL GKIVIDLTPA AYGPFVCPAI RNNDFLDKQN 130 140 150 160 170 180 VNMITCGGQA TIPIVHAINE VANVTYAEIV ATISSLSAGP GTRANIDEFT ITTKRGIEEI 190 200 210 220 230 240 GGADKGKAII ILNPAEPPIL MRDTIYCEVK DMDEVSIYEA IHKMVERVRT YVPGYSLKQE 250 260 270 280 290 PMFDGNRVTV FLEVEGAGDY FPPYAGNLDI MTAAALKVGE EFATQIVSEK KRGVMNEAK

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS41077.1.
RefSeq	NP_978469.1. NC_003909.8.
3D structure databases
ProteinModelPortal	Q739I5.
SMR	Q739I5. Positions 2-288.
ModBase	Search...
Protein-protein interaction databases
STRING	222523.BCE_2156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS41077; AAS41077; BCE_2156.
GeneID	2747923.
KEGG	bca:BCE_2156.
PATRIC	18853112. VBIBacCer118379_2058.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HOG000052149.
KO	K04073.
OMA	HAMVKEV.
ProtClustDB	PRK08300.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_BACC1

Accession

Primary (citable) accession number: Q739I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program