Q736W4 (KYNB_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	BCE_2786

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Kynurenine formamidase		PRO_0000362089

Sequences

	Sequence		Length	Mass (Da)
	Q736W4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B3D58C871A99DE1D	FASTA	209	23,185
	10 20 30 40 50 60 MKTSEWIDIS QPLNNDIATW PGDTPFSYEV SWPKEESGSV NVGKLTMSIH TGTHIDAPFH 70 80 90 100 110 120 FDNEGKKVID LDIQVYVGPV RIIDVSNLES IGKKELENFN LEGVERLLLR TSSHGKVNEF 130 140 150 160 170 180 PDVIPHLHAD IAPFLSEKGI RLIGVDVPSV DPLDDKELEA HHQLFKHGIH ILENVVLDHV 190 200 ADGDYELIAL PLALTDADGS PVRAVIRPI

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS41698.1.
RefSeq	NP_979090.1. NC_003909.8.
3D structure databases
ProteinModelPortal	Q736W4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q736W4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000025046; EBBACP00000024396; EBBACG00000025037.
GeneID	2751598.
GenomeReviews	Gene locus BCE_2786 in contig AE017194_GR.
KEGG	bca:BCE_2786.
NMPDR	fig|222523.1.peg.2762.
PATRIC	18854316. VBIBacCer118379_2658.
TIGR	BCE_2786.
Phylogenomic databases
eggNOG	COG1878.
GeneTree	EBGT00050000003083.
HOGENOM	HBG686791.
OMA	HTSKWPL.
ProtClustDB	CLSK904617.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_2786-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BACC1

Accession

Primary (citable) accession number: Q736W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program