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Protein

Ribonuclease Z

Gene

rnz

Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Zinc 1; catalyticUniRule annotation1
Metal bindingi65Zinc 1; catalyticUniRule annotation1
Active sitei67Proton acceptorUniRule annotation1
Metal bindingi67Zinc 2; catalyticUniRule annotation1
Metal bindingi68Zinc 2; catalyticUniRule annotation1
Metal bindingi141Zinc 1; catalyticUniRule annotation1
Metal bindingi212Zinc 1; catalyticUniRule annotation1
Metal bindingi212Zinc 2; catalyticUniRule annotation1
Metal bindingi270Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:BCE_4210
OrganismiBacillus cereus (strain ATCC 10987 / NRS 248)
Taxonomic identifieri222523 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002527 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001558401 – 307Ribonuclease ZAdd BLAST307

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ731F6
SMRiQ731F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000272419
KOiK00784
OMAiGTQRQMM

Family and domain databases

CDDicd07717 RNaseZ_ZiPD-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01818 RNase_Z_BN, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR013471 RNase_Z/BN
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
PF12706 Lactamase_B_2, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR02651 RNase_Z, 1 hit

Sequencei

Sequence statusi: Complete.

Q731F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVFLGTGA GVPSKGRNVS AIALQLLEER GQTWLFDCGE ATQHQILHTS
60 70 80 90 100
VRPRRIEKIF ITHLHGDHIF GLPGLLGSRS FQGGTTPLTV YGPKGIKQFI
110 120 130 140 150
EVALSVSTTH VKYPLEIVEI TEEGTVFEDN EFHVETKRLS HGIECFGYRI
160 170 180 190 200
IEKDIQGALL VDKLLEMGVK PGPLFKRLKD GEVVELENGT ILNGQDFIGP
210 220 230 240 250
PQKGRIITIL GDTRFCEASR ELAQDADVLV HEATFAAEDE QQAYDYFHST
260 270 280 290 300
SKQAASIALQ ANAKRLILTH ISSRYQGDTY KELLKEAREL FSNTEIATDL

KSFPVER
Length:307
Mass (Da):34,225
Last modified:July 5, 2004 - v1
Checksum:i321573FE331A8644
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA Translation: AAS43111.1
RefSeqiWP_000397447.1, NC_003909.8

Genome annotation databases

EnsemblBacteriaiAAS43111; AAS43111; BCE_4210
KEGGibca:BCE_4210

Similar proteinsi

Entry informationi

Entry nameiRNZ_BACC1
AccessioniPrimary (citable) accession number: Q731F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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