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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:BCE_4253
OrganismiBacillus cereus (strain ATCC 10987 / NRS 248)
Taxonomic identifieri222523 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002527 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002736401 – 452Exodeoxyribonuclease 7 large subunitAdd BLAST452

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiENAQVRC.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q731B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQYLTVTA LTRYIKTKIE YDPHLQSVWL KGEISNFKNH SRGHMYFTLK
60 70 80 90 100
DENARIAAVM FAGHNRNIKF RPENGMKVLV KGKISVYEAS GSYQIYIQDM
110 120 130 140 150
QPDGVGNLHL AYEQLKVRLE EEGLFSQVYK KTIPPYAKTI GVITSPTGAA
160 170 180 190 200
IRDIITTIKR RYPIGNVIVF PVLVQGESAA PSIVQAIRTA NEMEGIDVLI
210 220 230 240 250
VGRGGGSIEE LWAFNEEMVA RAIFKSEIPI ISAVGHETDF TIADFVADLR
260 270 280 290 300
APTPTAAAEL AAPNIIELQE KVLQRTLRLQ RAMRELVHKK EEKLQVLQKS
310 320 330 340 350
YAFRYPRQVY EQKEEQLDRA LEQLVLAKER YIDKKVNQLK QLSFYLEKHH
360 370 380 390 400
PSQKIMQTKV AVETLQKQLQ REMQTLLQTK EFAFVRAAQK LEALSPLKVM
410 420 430 440 450
MRGYGLVYDE EKQVLKSVKD VSLGDAVSVQ LQDGILDCSV SGIEERELNN

GK
Length:452
Mass (Da):51,368
Last modified:July 5, 2004 - v1
Checksum:i567F37FA7A57846E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA. Translation: AAS43154.1.
RefSeqiWP_000415266.1. NC_003909.8.

Genome annotation databases

EnsemblBacteriaiAAS43154; AAS43154; BCE_4253.
KEGGibca:BCE_4253.
PATRICi18857145. VBIBacCer118379_4071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA. Translation: AAS43154.1.
RefSeqiWP_000415266.1. NC_003909.8.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS43154; AAS43154; BCE_4253.
KEGGibca:BCE_4253.
PATRICi18857145. VBIBacCer118379_4071.

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiENAQVRC.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_BACC1
AccessioniPrimary (citable) accession number: Q731B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.