ID   AROE_BACC1              Reviewed;         277 AA.
AC   Q730K1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-JUN-2009, entry version 41.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BCE_4415;
OS   Bacillus cereus (strain ATCC 10987).
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=222523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14960714; DOI=10.1093/nar/gkh258;
RA   Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L.,
RA   Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F.,
RA   Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.;
RT   "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic
RT   adaptations and a large plasmid related to Bacillus anthracis pXO1.";
RL   Nucleic Acids Res. 32:977-988(2004).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AE017194; AAS43316.1; -; Genomic_DNA.
DR   RefSeq; NP_980708.1; -.
DR   HSSP; P15770; 1NYT.
DR   GeneID; 2748408; -.
DR   GenomeReviews; AE017194_GR; BCE_4415.
DR   KEGG; bca:BCE_4415; -.
DR   NMPDR; fig|222523.1.peg.4380; -.
DR   TIGR; BCE_4415; -.
DR   HOGENOM; Q730K1; -.
DR   OMA; Q730K1; IVSDIIY.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    277       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000021259.
FT   NP_BIND     127    131       NADP (By similarity).
FT   ACT_SITE     66     66       Proton acceptor (Potential).
SQ   SEQUENCE   277 AA;  30294 MW;  3492E61278FE50FC CRC64;
     MKQLYGVIGN PIGHSLSPVM HNDAFEHLNM DAHYHAFLVK EEVLGEAVRG LKALGISGFN
     VTTPHKVAIM DYLDEIDPLA KQIGAVNTVV HKDGKLIGYN TDGIGFVRAL QSISSKPLQE
     KRILLLGAGG ASRAIYFSLA DVGVKEIDVA NRTVDKAKEL ITACKATVHS VALSLEKATE
     EQGNYDIIIQ TTTIGMHPRV EHTPLQISSL NKGTIVSDII YNPFETKILC EAKEQGAMIQ
     NGIDMFVYQG ALAFEMWTGR TPNIERMKQL VIRKLGG
//