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Protein

Uridine kinase

Gene

udk

Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + uridine = ADP + UMP.UniRule annotation
ATP + cytidine = ADP + CMP.UniRule annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (udk)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (udk)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotation (EC:2.7.1.48UniRule annotation)
Alternative name(s):
Cytidine monophosphokinaseUniRule annotation
Uridine monophosphokinaseUniRule annotation
Gene namesi
Name:udkUniRule annotation
Ordered Locus Names:BCE_4462
OrganismiBacillus cereus (strain ATCC 10987 / NRS 248)
Taxonomic identifieri222523 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002527 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Uridine kinasePRO_1000017863Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ730F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262756.
KOiK00876.
OMAiTIENQAC.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00551. Uridine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
IPR026008. Uridine_kinase_.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q730F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTNKPVVIG IAGGSGSGKT SVTKAIFDHF KGHSILILEQ DYYYKDQSHL
60 70 80 90 100
PMEERLKTNY DHPLAFDNDL LIEHLQQLLA YKQVEKPVYD YTLHTRSDEI
110 120 130 140 150
IPVEPKDVII LEGILILEDP RLCELMDIKL FVDTDADLRI LRRMQRDIKE
160 170 180 190 200
RGRTMDSVID QYVNVVRPMH NQFIEPSKKF ADIIIPEGGQ NHVAIDIMVT
210
KIATILEQKV NL
Length:212
Mass (Da):24,338
Last modified:July 5, 2004 - v1
Checksum:iDF5747E176277308
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA. Translation: AAS43363.1.
RefSeqiWP_000537087.1. NC_003909.8.

Genome annotation databases

EnsemblBacteriaiAAS43363; AAS43363; BCE_4462.
KEGGibca:BCE_4462.
PATRICi18857558. VBIBacCer118379_4276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA. Translation: AAS43363.1.
RefSeqiWP_000537087.1. NC_003909.8.

3D structure databases

ProteinModelPortaliQ730F4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS43363; AAS43363; BCE_4462.
KEGGibca:BCE_4462.
PATRICi18857558. VBIBacCer118379_4276.

Phylogenomic databases

HOGENOMiHOG000262756.
KOiK00876.
OMAiTIENQAC.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00551. Uridine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
IPR026008. Uridine_kinase_.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiURK_BACC1
AccessioniPrimary (citable) accession number: Q730F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.