Q72ZA4 (ARLY_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BCE_4764

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137735

Sequences

	Sequence		Length	Mass (Da)
	Q72ZA4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 27BFC031FD535D05	FASTA	462	52,183
	10 20 30 40 50 60 MSKLWGGRFT EEAEAWVEEF GASISFDQQL VNQDINGSIA HVTMLAKQGI VTKEEAEKIK 70 80 90 100 110 120 IGLQYLLEEA KQNKLHFSVE AEDIHLNIEK MLIEKIGEVG GKLHTGRSRN DQVATDMHLY 130 140 150 160 170 180 LKEKVEHIIK ATKQLQTVLV HQAENNIETI MPGYTHLQRA QPISFAHHIL AYFWMLERDV 190 200 210 220 230 240 NRYEDSLKRI NISPLGAGAL AGTTFPIDRE YSAELLGFNG MYENSLDAVS DRDFILEFLS 250 260 270 280 290 300 NSSMLMMHLS RFCEELILWS SQEFQFIEMS DQYATGSSIM PQKKNPDMAE LIRGKTGRVY 310 320 330 340 350 360 GNLFSLLTVM KGLPLAYNKD LQEDKEGMFD TVKTVEGCLH IMAGMLETMT VNKEKMGQAV 370 380 390 400 410 420 TQDFSNATEI ADYLANKGLP FRQAHEIVGK LVLHCTQKGI YLVDVPLATY KEMSSLFEED 430 440 450 460 LYEVLSPYAA VKRRNSAGGT GFEQIEKALE KAKGLTKEVI KN

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS43665.1.
RefSeq	NP_981057.1. NC_003909.8.
3D structure databases
ProteinModelPortal	Q72ZA4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72ZA4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000028752; EBBACP00000028102; EBBACG00000028743.
GeneID	2751537.
GenomeReviews	Gene locus BCE_4764 in contig AE017194_GR.
KEGG	bca:BCE_4764.
NMPDR	fig|222523.1.peg.4729.
PATRIC	18858140. VBIBacCer118379_4565.
TIGR	BCE_4764.
Phylogenomic databases
eggNOG	COG0165.
GeneTree	EBGT00070000031828.
HOGENOM	HBG539632.
OMA	MAEDLIF.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_4764-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BACC1

Accession

Primary (citable) accession number: Q72ZA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program