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Protein

NAD kinase 2

Gene

nadK2

Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52Proton acceptorUniRule annotation1
Binding sitei151NADUniRule annotation1
Binding sitei153NADUniRule annotation1
Binding sitei188NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 53NADUniRule annotation2
Nucleotide bindingi124 – 125NADUniRule annotation2
Nucleotide bindingi164 – 169NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:BCE_4778
OrganismiBacillus cereus (strain ATCC 10987 / NRS 248)
Taxonomic identifieri222523 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002527 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296001 – 267NAD kinase 2Add BLAST267

Proteomic databases

PRIDEiQ72Z91

Structurei

3D structure databases

ProteinModelPortaliQ72Z91
SMRiQ72Z91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000275803
KOiK00858
OMAiEVRKYPL

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q72Z91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRRNLFFF YGDDKAKLVE KMKPIYRILE ENGFTILDHP KNANAIVSVG
60 70 80 90 100
DDATFLQAVR KTGFREDCLY AGISTKDEIS FYCDFHIDHV DIALQEITKN
110 120 130 140 150
EIEVRKYPTI EVDVDGSTSF HCLNEFSLRS SIIKTFVVDV HVDNLYFETF
160 170 180 190 200
RGDGLVVSTP TGSTAYNKSL RGAVVDPLIP CFQVSELASL NNNTYRTLGS
210 220 230 240 250
PFILNHERTL TLKLRPDGND YPVIGMDNEA LSIKQVEKAV VRLSDKQIKT
260
VKLKNNSFWE KVQRTFL
Length:267
Mass (Da):30,376
Last modified:July 5, 2004 - v1
Checksum:i641C15E116374141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA Translation: AAS43679.1
RefSeqiWP_000785165.1, NC_003909.8

Genome annotation databases

EnsemblBacteriaiAAS43679; AAS43679; BCE_4778
KEGGibca:BCE_4778

Similar proteinsi

Entry informationi

Entry nameiNADK2_BACC1
AccessioniPrimary (citable) accession number: Q72Z91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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