Q72Z91 (PPNK2_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase 2
Short name=Poly(P)/ATP NAD kinase 2
EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	BCE_4778

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP MF_00361		PRO_0000229600

Sequences

	Sequence		Length	Mass (Da)
	Q72Z91 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 641C15E116374141	FASTA	267	30,376
	10 20 30 40 50 60 MADRRNLFFF YGDDKAKLVE KMKPIYRILE ENGFTILDHP KNANAIVSVG DDATFLQAVR 70 80 90 100 110 120 KTGFREDCLY AGISTKDEIS FYCDFHIDHV DIALQEITKN EIEVRKYPTI EVDVDGSTSF 130 140 150 160 170 180 HCLNEFSLRS SIIKTFVVDV HVDNLYFETF RGDGLVVSTP TGSTAYNKSL RGAVVDPLIP 190 200 210 220 230 240 CFQVSELASL NNNTYRTLGS PFILNHERTL TLKLRPDGND YPVIGMDNEA LSIKQVEKAV 250 260 VRLSDKQIKT VKLKNNSFWE KVQRTFL

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS43679.1.
RefSeq	NP_981071.1. NC_003909.8.
3D structure databases
ProteinModelPortal	Q72Z91.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72Z91.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000028764; EBBACP00000028114; EBBACG00000028755.
GeneID	2751078.
GenomeReviews	Gene locus BCE_4778 in contig AE017194_GR.
KEGG	bca:BCE_4778.
NMPDR	fig|222523.1.peg.4743.
PATRIC	18858168. VBIBacCer118379_4579.
TIGR	BCE_4778.
Phylogenomic databases
eggNOG	COG0061.
GeneTree	EBGT00050000002705.
HOGENOM	HBG314020.
OMA	DDLHFET.
ProtClustDB	PRK03501.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_4778-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK2_BACC1

Accession

Primary (citable) accession number: Q72Z91

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program