Reviewed,
UniProtKB/Swiss-Prot Q72Y09 (MURB2_BACC1)
Last modified
February 9, 2010.
Version 42.
History...
Clusters with 100%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductase 2 EC=1.1.1.158 Alternative name(s): UDP-N-acetylmuramate dehydrogenase 2 | ||||
| Gene names |
| ||||
| Organism | Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 222523 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 305 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cell wall formation By similarity. HAMAP MF_00037 |
| Catalytic activity | UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037 |
| Cofactor | FAD By similarity. HAMAP MF_00037 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037 |
| Subcellular location | Cytoplasm Probable HAMAP MF_00037. |
| Sequence similarities | Belongs to the murB family. Contains 1 FAD-binding PCMH-type domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 305 | 305 | UDP-N-acetylenolpyruvoylglucosamine reductase 2 HAMAP MF_00037 | PRO_0000224655 | |||||
Regions | |||||||||
| Domain | 33 – 197 | 165 | FAD-binding PCMH-type | ||||||
Sites | |||||||||
| Active site | 176 | 1 | By similarity | ||||||
| Active site | 226 | 1 | Proton donor By similarity | ||||||
| Active site | 296 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017194 Genomic DNA. Translation: AAS44113.1. |
| RefSeq | NP_981505.1. |
3D structure databases | |
| SMR | Q72Y09. Positions 4-302. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q72Y09. |
Genome annotation databases | |
| GeneID | 2747207. |
| GenomeReviews | Gene locus BCE_5212 in contig AE017194_GR. |
| KEGG | bca:BCE_5212. |
| NMPDR | fig|222523.1.peg.5177. |
| TIGR | BCE_5212. |
Phylogenomic databases | |
| eggNOG | COG0812. |
| HOGENOM | HBG686573. |
| OMA | QPIREKT. |
Family and domain databases | |
| HAMAP | MF_00037. MurB. [Tree] |
| InterPro | IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR006094. Oxid_FAD_bind_N. [Graphical view] |
| Gene3D | G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.90.78.10. MurB_C. 1 hit. |
| PANTHER | PTHR21071. MurB. 1 hit. |
| Pfam | PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00179. murB. 1 hit. |
| PROSITE | PS51387. FAD_PCMH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MURB2_BACC1 | ||||||||
| Accession | Primary (citable) accession number: Q72Y09 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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