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Protein

Homoserine O-succinyltransferase

Gene

metA

Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-succinyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-succinyltransferase (metA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-succinyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BRENDAi2.3.1.46. 648.
UniPathwayiUPA00051; UER00075.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-succinyltransferaseUniRule annotation (EC:2.3.1.46UniRule annotation)
Alternative name(s):
Homoserine O-transsuccinylaseUniRule annotation
Short name:
HTSUniRule annotation
Gene namesi
Name:metAUniRule annotation
Ordered Locus Names:BCE_5534
OrganismiBacillus cereus (strain ATCC 10987 / NRS 248)
Taxonomic identifieri222523 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002527 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997361 – 301Homoserine O-succinyltransferaseAdd BLAST301

Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 41Combined sources6
Helixi47 – 58Combined sources12
Beta strandi61 – 63Combined sources3
Beta strandi65 – 70Combined sources6
Helixi92 – 95Combined sources4
Beta strandi100 – 105Combined sources6
Turni109 – 112Combined sources4
Helixi115 – 117Combined sources3
Helixi121 – 134Combined sources14
Beta strandi135 – 141Combined sources7
Helixi143 – 153Combined sources11
Beta strandi158 – 172Combined sources15
Helixi178 – 180Combined sources3
Beta strandi185 – 196Combined sources12
Helixi199 – 203Combined sources5
Beta strandi208 – 214Combined sources7
Turni215 – 217Combined sources3
Beta strandi218 – 224Combined sources7
Helixi225 – 227Combined sources3
Beta strandi229 – 232Combined sources4
Helixi242 – 253Combined sources12
Helixi265 – 267Combined sources3
Helixi278 – 291Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GHRX-ray2.40A1-301[»]
2VDJX-ray2.00A1-301[»]
ProteinModelPortaliQ72X44.
SMRiQ72X44.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72X44.

Family & Domainsi

Sequence similaritiesi

Belongs to the HTS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000115049.
KOiK00651.
OMAiWRSHRNL.

Family and domain databases

CDDicd03131. GATase1_HTS. 1 hit.
Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. Homoser_O_succinyltr. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
IPR033752. HTS_family.
[Graphical view]
PANTHERiPTHR20919. PTHR20919. 1 hit.
PfamiPF04204. HTS. 1 hit.
[Graphical view]
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72X44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIIIDKDLP ARKVLQEENI FVMTKERAET QDIRALKIAI LNLMPTKQET
60 70 80 90 100
EAQLLRLIGN TPLQLDVHLL HMESHLSRNV AQEHLTSFYK TFRDIENEKF
110 120 130 140 150
DGLIITGAPV ETLSFEEVDY WEELKRIMEY SKTNVTSTLH ICWGAQAGLY
160 170 180 190 200
HHYGVQKYPL KEKMFGVFEH EVREQHVKLL QGFDELFFAP HSRHTEVRES
210 220 230 240 250
DIREVKELTL LANSEEAGVH LVIGQEGRQV FALGHSEYSC DTLKQEYERD
260 270 280 290 300
RDKGLNIDVP KNYFKHDNPN EKPLVRWRSH GNLLFSNWLN YYVYQETPYV

L
Length:301
Mass (Da):35,340
Last modified:July 5, 2004 - v1
Checksum:i6476C52969F5067D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA. Translation: AAS44434.1.
RefSeqiWP_001121522.1. NC_003909.8.

Genome annotation databases

EnsemblBacteriaiAAS44434; AAS44434; BCE_5534.
KEGGibca:BCE_5534.
PATRICi18859664. VBIBacCer118379_5301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017194 Genomic DNA. Translation: AAS44434.1.
RefSeqiWP_001121522.1. NC_003909.8.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GHRX-ray2.40A1-301[»]
2VDJX-ray2.00A1-301[»]
ProteinModelPortaliQ72X44.
SMRiQ72X44.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi2750729.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS44434; AAS44434; BCE_5534.
KEGGibca:BCE_5534.
PATRICi18859664. VBIBacCer118379_5301.

Phylogenomic databases

HOGENOMiHOG000115049.
KOiK00651.
OMAiWRSHRNL.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00075.
BRENDAi2.3.1.46. 648.

Miscellaneous databases

EvolutionaryTraceiQ72X44.

Family and domain databases

CDDicd03131. GATase1_HTS. 1 hit.
Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. Homoser_O_succinyltr. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
IPR033752. HTS_family.
[Graphical view]
PANTHERiPTHR20919. PTHR20919. 1 hit.
PfamiPF04204. HTS. 1 hit.
[Graphical view]
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMETA_BACC1
AccessioniPrimary (citable) accession number: Q72X44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.