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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48S-adenosyl-L-methionineUniRule annotation1
Binding sitei73S-adenosyl-L-methionineUniRule annotation1
Binding sitei100S-adenosyl-L-methionineUniRule annotation1
Active sitei123By similarity1
Binding sitei123S-adenosyl-L-methionineUniRule annotation1
Binding sitei127SubstrateUniRule annotation1
Binding sitei159SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLINT267671:G1G07-134-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:LIC_10126
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Taxonomic identifieri267671 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000007037 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001713411 – 217tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST217

Proteomic databases

PaxDbiQ72W15

Interactioni

Protein-protein interaction databases

STRINGi267671.LIC10126

Structurei

3D structure databases

ProteinModelPortaliQ72W15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W7Y Bacteria
COG0220 LUCA
KOiK03439
OMAiPDPWHKS

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q72W15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQDLEQKLW SIASGIPFSS DYFLQASPIR KLKKENLFSK VFETYFLELG
60 70 80 90 100
SGWGEVAISM ALQRPNTGFI LMEKKFDRIR HTIREIEKHS LDNVKILCVN
110 120 130 140 150
FNWFLEEVFE ENLFSEILLN FPDPWPKKRH HKKRTVNSKF LESLKILLPE
160 170 180 190 200
KGKFYFATDY GPYARKIIRL FRDSKAFSPE KVELKSERNE IPVSHFERKK
210
REEGKRIYYI DRVLVQK
Length:217
Mass (Da):25,927
Last modified:July 5, 2004 - v1
Checksum:i5DDFEBA5D35B6967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016823 Genomic DNA Translation: AAS68759.1
RefSeqiWP_000249515.1, NC_005823.1

Genome annotation databases

EnsemblBacteriaiAAS68759; AAS68759; LIC_10126
KEGGilic:LIC_10126

Similar proteinsi

Entry informationi

Entry nameiTRMB_LEPIC
AccessioniPrimary (citable) accession number: Q72W15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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