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Q72VI8 (GCSP_LEPIC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:LIC_10309
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) [Complete proteome] [HAMAP]
Taxonomic identifier267671 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length964 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 964964Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166916

Amino acid modifications

Modified residue7131N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72VI8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 67CEEDC4FE40C401

FASTA964106,324
        10         20         30         40         50         60 
MNSTLQNQTK TNLEKVGTDP LDTFPRRHIG PNLQQTAEML KELGLSSVEE LIDKAVPVGI 

        70         80         90        100        110        120 
RLKKSLDLPK ASTEHKILQN LKGIASQNQV FRSYIGAGYH SCIIPGVIQR NILENPGWYT 

       130        140        150        160        170        180 
AYTPYQAEIS QGRLEALLNF QTMIIDLTGL EISNASLLDE GTAAAEAMFL AYSVRKNETA 

       190        200        210        220        230        240 
KKFFVSELCH PQTIDVVVTR ANPLGIEVQI GNHESIELNE DFFGVLLQYP ATDGKIIDYT 

       250        260        270        280        290        300 
SFIQRSHNVG AISTVAADLL ALTLLKSPGE MGADIAVGSS QRFGLPLGFG GPHAGYFATK 

       310        320        330        340        350        360 
DEFKRSMPGR LIGVSKDSQG NSGLRLSLQT REQHIRRDKA TSNICTAQVL LAVISSMYAV 

       370        380        390        400        410        420 
YHGPEGLKNI ATRIYKFTSI FANVLKNAGF SITNEFFFDT ITIQAGTKVQ EILNRAYSKK 

       430        440        450        460        470        480 
INFREYKDGK IGITLDETVN LEDLKDLLEI FEIKNTDIEK LFVDVSNVPD SFKRKTSYLT 

       490        500        510        520        530        540 
HPVFQSHHTE TKMLRYIRKL ESRDLSLTTS MIPLGSCTMK LNATTEMYPV TWPEFGAIHP 

       550        560        570        580        590        600 
FAPADQTKGY KIIFEQLEKW LCEITGFAGV SLQPNAGSQG EYAGLLAIRR YHESRNESYR 

       610        620        630        640        650        660 
NVCLIPISAH GTNPASAAMA GFQVVVVSCD PNGNVDLEDL KAKAEEHKKD LAALMITYPS 

       670        680        690        700        710        720 
THGVFEESVK EICQIVHSCG GQVYMDGANM NAQVGLTSPG EIGADVCHLN LHKTFCIPHG 

       730        740        750        760        770        780 
GGGPGVGPIG VAKHLVPFLP GHVLVDNATG NEHGAVSAAP WGSASIVLIS WVYIALMGSE 

       790        800        810        820        830        840 
GLTNATRNSI LNANYIAKRL EKVYPVLYKG KNGFVAHECI LDLRPFKKSA GIEVEDVAKR 

       850        860        870        880        890        900 
LIDYGFHAPT MSFPVPGTLM IEPTESESLE ELDRFCEAML LIYQEILDVQ SGTLDKTDNP 

       910        920        930        940        950        960 
LKNSPHTAAM VTSDRWDHLY PRERAAYPAS WLKDHKFWPY VGRVDNVYGD RNLVCSCLPI 


ESYQ 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016823 Genomic DNA. Translation: AAS68936.1.
RefSeqYP_000299.1. NC_005823.1.

3D structure databases

ProteinModelPortalQ72VI8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267671.LIC10309.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS68936; AAS68936; LIC_10309.
GeneID2770466.
KEGGlic:LIC10309.
PATRIC22372375. VBILepInt6257_0365.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycLINT267671:GHQI-308-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_LEPIC
AccessionPrimary (citable) accession number: Q72VI8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families