Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q72U64 (THIM_LEPIC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:LIC_10800
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) [Complete proteome] [HAMAP]
Taxonomic identifier267671 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156941

Sites

Binding site551Substrate; via amide nitrogen By similarity
Binding site1301ATP By similarity
Binding site1761ATP By similarity
Binding site2031Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72U64 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BA1D033D82DEA83F

FASTA26527,372
        10         20         30         40         50         60 
MSKTTIIERI WPAKEIIEDL SELRKQSPLT HVITNIVVTN WTANVLLAIG SSPAMVIAKE 

        70         80         90        100        110        120 
EAGEFAKIAS GLLINIGTVT SNDAITMKIA AEAAHQAKIP WVLDPVAVGA LGFRTELAKE 

       130        140        150        160        170        180 
LLNFKPTVIR GNASEILALA GTDGGGKGVD STALSSDALP LAQMLAEKTG AVIAISGEID 

       190        200        210        220        230        240 
YVTNGKETIS ISGGDPIMTK VTGVGCSLGG VIASFLGVQK DPLRATATAS AVFAIAGTRS 

       250        260 
AKISKGSGSF AVNFLDQLNL LSTEK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016823 Genomic DNA. Translation: AAS69414.1.
RefSeqYP_000777.1. NC_005823.1.

3D structure databases

ProteinModelPortalQ72U64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267671.LIC10800.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS69414; AAS69414; LIC_10800.
GeneID2772939.
KEGGlic:LIC10800.
PATRIC22373626. VBILepInt6257_0986.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00878.
OMAQTFTANV.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycLINT267671:GHQI-800-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_LEPIC
AccessionPrimary (citable) accession number: Q72U64
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways