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Protein
Submitted name:

D-alanine--d-alanine ligase

Gene

ddl

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--d-alanine ligaseImported
Gene namesi
Name:ddlImported
Ordered Locus Names:LIC_11304Imported
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)Imported
Taxonomic identifieri267671 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000007037 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm SAAS annotation

Keywords - Cellular componenti

CytoplasmSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ72SS1.

Interactioni

Protein-protein interaction databases

STRINGi267671.LIC11304.

Structurei

3D structure databases

ProteinModelPortaliQ72SS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 355ATP-graspInterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108N9N. Bacteria.
COG1181. LUCA.
KOiK01921.
OMAiQMVEYEV.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011095. Dala_Dala_lig_C.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72SS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKMTPTVLV YADLHEFEGN FPEIYKQEWE SKKSVDAILE LLNEVGESIE
60 70 80 90 100
LVVTPNELLE KLKCYCDLDF SKRPVIFHLM EGFCSRNRES LIPAVAELFG
110 120 130 140 150
FPHTGSDSYS QNVSLDKNLT RIFAQSIGVP VASGFWIRSK DVLFKELLQL
160 170 180 190 200
ECNSEIKKRF SFSKGNELNL KNFSFPAFIK PAGEGSSLGI GEKNIIYSFE
210 220 230 240 250
ELNTLLSEAP EIFFPYLLEE YLTGNEYTIS VIGSATFGYK VSSAGRLILR
260 270 280 290 300
EDLKVEDVYG EKTKSKSIMP ETLVFDCPKD LEVIIQQQSV LFCESLGTSG
310 320 330 340 350
PARLDWKLDS LGNPFFLEMN LTPGLSPFYS TFPICYRHSL GDEKNLFQEI
360 370
LKIARLDFET DRFLYSKNKI RNLI
Length:374
Mass (Da):42,571
Last modified:July 5, 2004 - v1
Checksum:iF3944060831D47BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016823 Genomic DNA. Translation: AAS69907.1.
RefSeqiWP_001038596.1. NC_005823.1.

Genome annotation databases

EnsemblBacteriaiAAS69907; AAS69907; LIC_11304.
KEGGilic:LIC_11304.
PATRICi22374883. VBILepInt6257_1609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016823 Genomic DNA. Translation: AAS69907.1.
RefSeqiWP_001038596.1. NC_005823.1.

3D structure databases

ProteinModelPortaliQ72SS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267671.LIC11304.

Proteomic databases

PaxDbiQ72SS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS69907; AAS69907; LIC_11304.
KEGGilic:LIC_11304.
PATRICi22374883. VBILepInt6257_1609.

Phylogenomic databases

eggNOGiENOG4108N9N. Bacteria.
COG1181. LUCA.
KOiK01921.
OMAiQMVEYEV.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011095. Dala_Dala_lig_C.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ72SS1_LEPIC
AccessioniPrimary (citable) accession number: Q72SS1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.