Q72SS1 (Q72SS1_LEPIC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
D-alanine--d-alanine ligase EMBL AAS69907.1

Gene names

Name:	ddl EMBL AAS69907.1
Ordered Locus Names:	LIC_11304

Organism

Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) [Complete proteome] [HAMAP] EMBL AAS69907.1

Taxonomic identifier

267671 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Leptospiraceae › Leptospira › Leptospira interrogans › Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. SAAS SAAS005905
Catalytic activity	ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. SAAS SAAS005905
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005905
Subcellular location	Cytoplasm By similarity SAAS SAAS005905.
Sequence similarities	Contains 1 ATP-grasp domain. SAAS SAAS005905

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation SAAS SAAS005905 Peptidoglycan synthesis SAAS SAAS005905
Cellular component	Cytoplasm SAAS SAAS005905
Ligand	ATP-binding SAAS SAAS005905 Magnesium SAAS SAAS005905 Manganese SAAS SAAS005905 Metal-binding SAAS SAAS005905 Nucleotide-binding
Molecular function	Ligase SAAS SAAS005905 EMBL AAS69907.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-D-alanine ligase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q72SS1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F3944060831D47BA	FASTA	374	42,571
	10 20 30 40 50 60 MNKMTPTVLV YADLHEFEGN FPEIYKQEWE SKKSVDAILE LLNEVGESIE LVVTPNELLE 70 80 90 100 110 120 KLKCYCDLDF SKRPVIFHLM EGFCSRNRES LIPAVAELFG FPHTGSDSYS QNVSLDKNLT 130 140 150 160 170 180 RIFAQSIGVP VASGFWIRSK DVLFKELLQL ECNSEIKKRF SFSKGNELNL KNFSFPAFIK 190 200 210 220 230 240 PAGEGSSLGI GEKNIIYSFE ELNTLLSEAP EIFFPYLLEE YLTGNEYTIS VIGSATFGYK 250 260 270 280 290 300 VSSAGRLILR EDLKVEDVYG EKTKSKSIMP ETLVFDCPKD LEVIIQQQSV LFCESLGTSG 310 320 330 340 350 360 PARLDWKLDS LGNPFFLEMN LTPGLSPFYS TFPICYRHSL GDEKNLFQEI LKIARLDFET 370 DRFLYSKNKI RNLI

References

[1]

"Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis." Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B., Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V., Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L., Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S. , Ferro M.I.T., Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H., Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M., Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L., Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A., Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A., Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A. J. Bacteriol. 186:2164-2172(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fiocruz L1-130.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016823 Genomic DNA. Translation: AAS69907.1.
RefSeq	YP_001270.1. NC_005823.1.
3D structure databases
ProteinModelPortal	Q72SS1.
ModBase	Search...
Protein-protein interaction databases
STRING	267671.LIC11304.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS69907; AAS69907; LIC_11304.
GeneID	2770442.
KEGG	lic:LIC11304.
PATRIC	22374883. VBILepInt6257_1609.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01921.
OMA	QMVEYEV.
ProtClustDB	CLSK574542.
Enzyme and pathway databases
BioCyc	LINT267671:GHQI-1574-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.30.1490.20. 1 hit. 3.30.470.20. 2 hits.
InterPro	IPR011761. ATP-grasp. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR016185. PreATP-grasp_dom. [Graphical view]
PANTHER	PTHR23132. PTHR23132. 1 hit.
Pfam	PF07478. Dala_Dala_lig_C. 1 hit. [Graphical view]
SUPFAM	SSF52440. PreATP-grasp-like. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q72SS1_LEPIC

Accession

Primary (citable) accession number: Q72SS1

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)