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Q72QL1 (SYR_LEPIC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:LIC_12102
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) [Complete proteome] [HAMAP]
Taxonomic identifier267671 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence AAS70673.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151570

Regions

Motif133 – 14311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q72QL1 [UniParc].

Last modified August 10, 2010. Version 2.
Checksum: E2B7702058C628AC

FASTA58666,821
        10         20         30         40         50         60 
MKENETLKQI VLKTLEESVN SLISSFPEVE KEAFKIKIEY SRDEKFGDYS TSFALENSKL 

        70         80         90        100        110        120 
LKRNPIQVSK ELVEILQKRT DLFEKVDFTP PGFVNFRIST SFLLNYIETS VLSGNYFPKV 

       130        140        150        160        170        180 
DLPLKINLEF VSANPTGPLN IVSARAAANG DTMASLLKAI GHNVDKEFYI NDYGNQVFLL 

       190        200        210        220        230        240 
GVSTLVRIRE LKGEEGTQQE TTDDTPIEII LEKNILPAEG YRGEYIKDIA SSLLKDPKKN 

       250        260        270        280        290        300 
VTIENLLKQK KYKELAELCA VWTIENNLIW QRKDLDAFGV EFDCYFSERT LHEADKVLSV 

       310        320        330        340        350        360 
MKDLEKSGKI FQEDGKKVFR STEYGDDKDR VVVRDDGRPT YLLADIAYHK DKIERGYDKI 

       370        380        390        400        410        420 
YDIWGPDHHG YISRLSGAVQ SLGYKKENFK VIISQQVNLL ESGQKVKMSK RAGSFQTMSD 

       430        440        450        460        470        480 
LIGFLGKHGK DVGRYFFVMR SLDAPLDFDL DLAKDESDKN PVFYLQYAHA RICSIFKEVG 

       490        500        510        520        530        540 
DQTSKEAAAI LEMSEERKRL LFWIARFPEE IFDSANAMEP HRVTNYLQSF AKAFTSFYLA 

       550        560        570        580 
KDNRLKDASK EVRLGLARIC LAAKNVLAEG LKLIGVSAPE RMEKEN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016823 Genomic DNA. Translation: AAS70673.1. Different initiation.
RefSeqYP_002036.1. NC_005823.1.

3D structure databases

ProteinModelPortalQ72QL1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267671.LIC12102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS70673; AAS70673; LIC_12102.
GeneID2771269.
KEGGlic:LIC12102.
PATRIC22376690. VBILepInt6257_2505.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01887.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycLINT267671:GHQI-2094-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_LEPIC
AccessionPrimary (citable) accession number: Q72QL1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: August 10, 2010
Last modified: April 16, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries