Reviewed, UniProtKB/Swiss-Prot Q72PJ7 (ODO1_LEPIC)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate dehydrogenase E1 component
    EC=1.2.4.2
Alternative name(s):
    Alpha-ketoglutarate dehydrogenase

Gene names

Name:	sucA
Synonyms:	odhA
Ordered Locus Names:	LIC_12474

Organism

Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni [Complete proteome] [HAMAP]

Taxonomic identifier

44275 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length	920 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamin pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 920	920	2-oxoglutarate dehydrogenase E1 component		PRO_0000162173

Sequences

	Sequence		Length	Mass (Da)
	Q72PJ7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8A4513F3F1B3DD0A	FASTA	920	103,922
	10 20 30 40 50 60 MKIEKLMALY GENGALLEEL YNQYKLNPET LDKEWKSFFQ EVDTNGLANG SGYTNGNGKS 70 80 90 100 110 120 AVATSFTDAQ AASIREMGII NLLNAYRRQG HLAAKLDPLG IQKPNRTFID SKLHNISPAD 130 140 150 160 170 180 IDTVVDSETL GRVKLAEIVD LYEKVYCNTI GAEHFYLVND EEREWLQKKM ESPEFLAPLP 190 200 210 220 230 240 RGIKLRLFEK LFQADYFETF LAKKYVGKKR FSLEGGESFI PLLDTIVEEA GYHQMDGLVI 250 260 270 280 290 300 GMAHRGRLNV LVNIIEKPAS LIFAEFEEKT DKDNLSYADV KYHLGYSNSR MTTSGKEVKL 310 320 330 340 350 360 SLAFNPSHLE CVDPVVTGSV RARQTLIGDK DRSKYMPILI HGDAAFAGQG VVAETLNLMN 370 380 390 400 410 420 LEGYTTGGTF HIVVNNQIGF TTLPDESRST LYATDLAKGF QIPIIHVNGD DPEAVYRVVK 430 440 450 460 470 480 LGMEYRQKFK KDFIIDLVCY RRLGHNETDE PAFTQPKMYA IIKNHPPTVK LYEKRLVEEG 490 500 510 520 530 540 DIPQEDIDFI KNGSMHGLED SFQRAKEQDV KIRVDTMQGV WSKFSKDSLD SEPATKLLAE 550 560 570 580 590 600 QMHGIVQALT SVPQGFTPNS KLVKLLQSRK EMAEGKIPVD WGFAEALSFG SILESGFRIR 610 620 630 640 650 660 LSGQDSQRGT FSHRHAVLVD TNTNEKYIPL NHISSKQAKA EIINSSLSEF SVLGFEYGYS 670 680 690 700 710 720 LSDPNALVMW EAQFGDFANS AQVIFDQFIS SSEVKWQRLS GLIMLLPHGY EGQGPEHSSA 730 740 750 760 770 780 RLERFLQLCA LDNMQVCNLT TAAQYFHLLR RQMLRNYRKP LVIVTPKSLL RFPASLSPVE 790 800 810 820 830 840 DILQGAFREI LIDDSGSKPD KIEKVVFSAG KVYYDLMKYK DENKIKNVAL VRVEQIYPFP 850 860 870 880 890 900 AKEIQSSLKT FKNAKQFVWC QEEPKNQGAW FFVRERIEEL LPGNARLVYA GRHESPSPAA 910 920 GHMKLHLQEQ DQLVLDAFQA

References

[1]

"Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis." Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B., Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V., Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L., Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S. , Ferro M.I.T., Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H., Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M., Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L., Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A., Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A., Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A. J. Bacteriol. 186:2164-2172(2004) [PubMed: 15028702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fiocruz L1-130.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016823 Genomic DNA. Translation: AAS71039.1.
RefSeq	YP_002402.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2770761.
GenomeReviews	Gene locus LIC_12474 in contig AE016823_GR.
KEGG	lic:LIC12474.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q72PJ7.
Enzyme and pathway databases
BioCyc	LINT267671:LIC_12474-MON.
Family and domain databases
HAMAP	MF_01169. [Tree]
InterPro	IPR011603. 2oxoglutarate_DHase_E1. IPR001017. DHase_E1. IPR005475. Transketo_Cen_R. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_LEPIC

Accession

Primary (citable) accession number: Q72PJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	July 5, 2004
Last modified:	November 4, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)