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Q72PJ7

- ODO1_LEPIC

UniProt

Q72PJ7 - ODO1_LEPIC

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciLINT267671:GHQI-2467-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenaseUniRule annotation
    Gene namesi
    Name:sucAUniRule annotation
    Synonyms:odhAUniRule annotation
    Ordered Locus Names:LIC_12474
    OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
    Taxonomic identifieri267671 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000007037: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9209202-oxoglutarate dehydrogenase E1 componentPRO_0000162173Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi267671.LIC12474.

    Structurei

    3D structure databases

    ProteinModelPortaliQ72PJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    KOiK00164.
    OMAiGHQNANL.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q72PJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIEKLMALY GENGALLEEL YNQYKLNPET LDKEWKSFFQ EVDTNGLANG    50
    SGYTNGNGKS AVATSFTDAQ AASIREMGII NLLNAYRRQG HLAAKLDPLG 100
    IQKPNRTFID SKLHNISPAD IDTVVDSETL GRVKLAEIVD LYEKVYCNTI 150
    GAEHFYLVND EEREWLQKKM ESPEFLAPLP RGIKLRLFEK LFQADYFETF 200
    LAKKYVGKKR FSLEGGESFI PLLDTIVEEA GYHQMDGLVI GMAHRGRLNV 250
    LVNIIEKPAS LIFAEFEEKT DKDNLSYADV KYHLGYSNSR MTTSGKEVKL 300
    SLAFNPSHLE CVDPVVTGSV RARQTLIGDK DRSKYMPILI HGDAAFAGQG 350
    VVAETLNLMN LEGYTTGGTF HIVVNNQIGF TTLPDESRST LYATDLAKGF 400
    QIPIIHVNGD DPEAVYRVVK LGMEYRQKFK KDFIIDLVCY RRLGHNETDE 450
    PAFTQPKMYA IIKNHPPTVK LYEKRLVEEG DIPQEDIDFI KNGSMHGLED 500
    SFQRAKEQDV KIRVDTMQGV WSKFSKDSLD SEPATKLLAE QMHGIVQALT 550
    SVPQGFTPNS KLVKLLQSRK EMAEGKIPVD WGFAEALSFG SILESGFRIR 600
    LSGQDSQRGT FSHRHAVLVD TNTNEKYIPL NHISSKQAKA EIINSSLSEF 650
    SVLGFEYGYS LSDPNALVMW EAQFGDFANS AQVIFDQFIS SSEVKWQRLS 700
    GLIMLLPHGY EGQGPEHSSA RLERFLQLCA LDNMQVCNLT TAAQYFHLLR 750
    RQMLRNYRKP LVIVTPKSLL RFPASLSPVE DILQGAFREI LIDDSGSKPD 800
    KIEKVVFSAG KVYYDLMKYK DENKIKNVAL VRVEQIYPFP AKEIQSSLKT 850
    FKNAKQFVWC QEEPKNQGAW FFVRERIEEL LPGNARLVYA GRHESPSPAA 900
    GHMKLHLQEQ DQLVLDAFQA 920
    Length:920
    Mass (Da):103,922
    Last modified:July 5, 2004 - v1
    Checksum:i8A4513F3F1B3DD0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016823 Genomic DNA. Translation: AAS71039.1.
    RefSeqiYP_002402.1. NC_005823.1.

    Genome annotation databases

    EnsemblBacteriaiAAS71039; AAS71039; LIC_12474.
    GeneIDi2770761.
    KEGGilic:LIC12474.
    PATRICi22377606. VBILepInt6257_2961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016823 Genomic DNA. Translation: AAS71039.1 .
    RefSeqi YP_002402.1. NC_005823.1.

    3D structure databases

    ProteinModelPortali Q72PJ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267671.LIC12474.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS71039 ; AAS71039 ; LIC_12474 .
    GeneIDi 2770761.
    KEGGi lic:LIC12474.
    PATRICi 22377606. VBILepInt6257_2961.

    Phylogenomic databases

    KOi K00164.
    OMAi GHQNANL.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci LINT267671:GHQI-2467-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis."
      Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B., Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V., Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L., Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S.
      , Ferro M.I.T., Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H., Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M., Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L., Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A., Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A., Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A.
      J. Bacteriol. 186:2164-2172(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fiocruz L1-130.

    Entry informationi

    Entry nameiODO1_LEPIC
    AccessioniPrimary (citable) accession number: Q72PJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3