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Q72P44 (PHL1_LEPIC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sphingomyelinase C 1
EC=3.1.4.12
Alternative name(s):
Sphingomyelin phosphodiesterase 1
Short name=SMase 1
Gene names
Name:sph1
Ordered Locus Names:LIC_12632
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) [Complete proteome] [HAMAP]
Taxonomic identifier267671 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Sphingomyelin + H2O = N-acylsphingosine + choline phosphate.

Subcellular location

Secreted By similarity.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsphingomyelin phosphodiesterase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3636 Potential
Chain37 – 596560Sphingomyelinase C 1
PRO_0000022049

Sequences

Sequence LengthMass (Da)Tools
Q72P44 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 05A979DB24D16F6C

FASTA59668,095
        10         20         30         40         50         60 
MITKRNIPCK KNWKYKKKSI SLTLITICYM FLFLTSCKPG KQNSINLLLL LLNTLDNKNV 

        70         80         90        100        110        120 
NEKIEDSTNT DPSSNVNEED ENSINANAND NAPSDSDSSN PRSPDKNPVN PTSPNSSSAD 

       130        140        150        160        170        180 
IGIKILSHSI FMAPTNLSSW GDLGQEERAQ RIASSSYIKN QDIIVFEGLS HNNAEKILLE 

       190        200        210        220        230        240 
KIRSEYPYQT NVVGRTKKGW NATLGAYTTS PMANGGVIIV SKWPIEEKVQ YIFNNSNCGQ 

       250        260        270        280        290        300 
DQYYNKGFAY VKINKDGKKF HVIGTQLQAR EPDCFNSGET IRKLQLNDIK SFIDSKDIPK 

       310        320        330        340        350        360 
DETVLITGDL NIIKGSNEYF DMISKLNVNE PRYVGVPFTL DTKTNALAAY YYEKEKPIYL 

       370        380        390        400        410        420 
DYILVSKLHA QPPVWQNLAY DPISNTTWKR SDGYTSYEFS DRYPVYGFIY ADSSTPTKSG 

       430        440        450        460        470        480 
HKRKYDQVSF QSTFNRKFIQ ADHNKKDGWL KADTRIKTDF TKFNLLQENV SESNPSCMNS 

       490        500        510        520        530        540 
GSVRIESSYY LNYYWNWFIG AASGDYGYYT KFNNGSDSLG IKNLDNGCLK DGSRVAFYDW 

       550        560        570        580        590 
DTIGGGYYYL TVWDKGSWKE HLFLWVQSFL SSREIFYLHL DSNPPKDWSK DLIYHH

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016823 Genomic DNA. Translation: AAS71192.1.
RefSeqYP_002555.1. NC_005823.1.

3D structure databases

ProteinModelPortalQ72P44.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2772092.
GenomeReviewsGene locus LIC_12632 in contig AE016823_GR.
KEGGlic:LIC12632.
NMPDRfig|267671.1.peg.2555.
PATRIC22378009. VBILepInt6257_3158.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG110590.
OMALITICYM.
ProtClustDBCLSK638897.

Enzyme and pathway databases

BioCycLINT267671:LIC_12632-MONOMER.

Family and domain databases

InterProIPR005135. Endo/exonuclease/phosphatase.
IPR017766. Sphingomyelinase/PLipase_C.
[Graphical view]
KOK01117.
PfamPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMSSF56219. Exo_endo_phos. 1 hit.
TIGRFAMsTIGR03395. Sphingomy. 1 hit.
ProtoNetSearch...

Entry information

Entry namePHL1_LEPIC
AccessionPrimary (citable) accession number: Q72P44
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
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