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Protein

Glutamate 5-kinase

Gene

proB

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21ATPUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei163Substrate; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi217 – 223ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00098; UER00359

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:LIC_12772
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Taxonomic identifieri267671 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000007037 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001096851 – 290Glutamate 5-kinaseAdd BLAST290

Proteomic databases

PaxDbiQ72NQ8

Interactioni

Protein-protein interaction databases

STRINGi267671.LIC12772

Structurei

3D structure databases

ProteinModelPortaliQ72NQ8
SMRiQ72NQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGT Bacteria
COG0263 LUCA
KOiK00931
OMAiNMINCYE

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_00456 ProB, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR001057 Glu/AcGlu_kinase
IPR011529 Glu_5kinase
IPR005715 Glu_5kinase/COase_Synthase
IPR019797 Glutamate_5-kinase_CS
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF000729 GK, 1 hit
PRINTSiPR00474 GLU5KINASE
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR01027 proB, 1 hit
PROSITEiView protein in PROSITE
PS00902 GLUTAMATE_5_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q72NQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPERNSLSE KIRNAEKIVI KVGSARLSGL PSEVNDFLFQ LVSDIRHLRD
60 70 80 90 100
LGKKVILVSS GAIARGRLLL SELPSTISSG DSLAEKQALA AMGQNRLVNL
110 120 130 140 150
YDSFFSKVNL SIAQILFGVL DLESKEGYKN LKNTFTQLVE WGILPVVNEN
160 170 180 190 200
DSVATEEVKF GDNDMLSALV SLIVEADLLI ILTGVDGFLK EEKVVPFLEK
210 220 230 240 250
ISKEDLGLAG GPSGPGTGGM FTKLKSAGLL SEAGIPTAIL NGKKMHVIRE
260 270 280 290
FLEKNSIGTL VAPSGNRVFS EEDVKEIIRK NRNGNGGNSL
Length:290
Mass (Da):31,307
Last modified:July 5, 2004 - v1
Checksum:i24CB9C7E6A78E335
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016823 Genomic DNA Translation: AAS71328.1
RefSeqiWP_000801906.1, NC_005823.1

Genome annotation databases

EnsemblBacteriaiAAS71328; AAS71328; LIC_12772
KEGGilic:LIC_12772

Similar proteinsi

Entry informationi

Entry nameiPROB_LEPIC
AccessioniPrimary (citable) accession number: Q72NQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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