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Q72LZ4 (MTAP_LEPIC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
S-methyl-5'-thioadenosine phosphorylase

EC=2.4.2.28
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name=MTA phosphorylase
Short name=MTAP
Gene names
Name:mtnP
Ordered Locus Names:LIC_13399
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) [Complete proteome] [HAMAP]
Taxonomic identifier267671 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity. HAMAP-Rule MF_01963

Catalytic activity

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01963

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. HAMAP-Rule MF_01963

Subunit structure

Homohexamer. Dimer of a homotrimer By similarity. HAMAP-Rule MF_01963

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287S-methyl-5'-thioadenosine phosphorylase HAMAP-Rule MF_01963
PRO_0000184549

Regions

Region55 – 562Phosphate binding By similarity
Region210 – 2123Substrate binding By similarity

Sites

Binding site131Phosphate By similarity
Binding site1861Substrate; via amide nitrogen By similarity
Binding site1871Phosphate By similarity
Site1681Important for substrate specificity By similarity
Site2231Important for substrate specificity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q72LZ4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2DE328C06A622457

FASTA28732,069
        10         20         30         40         50         60 
MSYNVRVAII GGTGLYSLEG MELIEEIFPD TPWGKPSDKI KIGKYKGKLI AFLPRHGIGH 

        70         80         90        100        110        120 
FLSPPEVPNH ANICALKQLG VEEIVAFSSV GSLREEIKPL DFVLPSQIID RTRFRNSTYF 

       130        140        150        160        170        180 
GNGVVAHAPF AEPFSPNLSK RIAQTAKKIG LEIHLDKTLV CMEGPLFSTK AESHLYRSWG 

       190        200        210        220        230        240 
ADIINMTVLP EAKLAREAEI AYQMICMSTD YDCWREGEES VTVEMVIANL TKNAETAKKL 

       250        260        270        280 
LSELIHVLGN GDDLSLKNST RYSIITAPEK RNPETVKKLR VLFPEYF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016823 Genomic DNA. Translation: AAS71939.1.
RefSeqYP_003302.1. NC_005823.1.

3D structure databases

ProteinModelPortalQ72LZ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267671.LIC13399.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS71939; AAS71939; LIC_13399.
GeneID2771325.
KEGGlic:LIC13399.
PATRIC22379935. VBILepInt6257_4115.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00772.
OMACEAQLCY.
OrthoDBEOG6KHFXC.

Enzyme and pathway databases

BioCycLINT267671:GHQI-3390-MONOMER.
UniPathwayUPA00904; UER00873.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
HAMAPMF_01963. MTAP.
InterProIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01694. MTAP. 1 hit.
PROSITEPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTAP_LEPIC
AccessionPrimary (citable) accession number: Q72LZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways