Q72LG3 (FENR_THET2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferredoxin--NADP reductase
Short name=FNR
Short name=Fd-NADP+ reductase
EC=1.18.1.2

Gene names

Ordered Locus Names:

TT_C0096

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP MF_01685
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_01685
Subunit structure	Homodimer By similarity. HAMAP MF_01685
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Ferredoxin--NADP reductase HAMAP MF_01685		PRO_0000364980
Sites
	Binding site	35	1	FAD By similarity
	Binding site	43	1	FAD By similarity
	Binding site	48	1	FAD By similarity
	Binding site	88	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	122	1	FAD; via amide nitrogen By similarity
	Binding site	287	1	FAD By similarity
	Binding site	328	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q72LG3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B6B5D4653C942CB8	FASTA	335	36,177
	10 20 30 40 50 60 MAADHTDVLI VGAGPAGLFA GFYVGMRGLS FRFVDPLPEP GGQLTALYPE KYIYDVAGFP 70 80 90 100 110 120 KVYAKDLVKG LVEQVAPFNP VYSLGERAET LEREGDLFKV TTSQGNAYTA KAVIIAAGVG 130 140 150 160 170 180 AFEPRRIGAP GEREFEGRGV YYAVKSKAEF QGKRVLIVGG GDSAVDWALN LLDTARRITL 190 200 210 220 230 240 IHRRPQFRAH EASVKELMKA HEEGRLEVLT PYELRRVEGD ERVRWAVVFH NQTQEELALE 250 260 270 280 290 300 VDAVLILAGY ITKLGPLANW GLALEKNKIK VDTTMATSIP GVYACGDIVT YPGKLPLIVL 310 320 330 GFGEAAIAAN HAAAYANPAL KVNPGHSSEK AAPGT

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB27 / ATCC BAA-163 / DSM 7039.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS80444.1.
RefSeq	YP_004071.1. NC_005835.1.
3D structure databases
HSSP	HSSP built from PDB template 2A87 based on UniProtKB P52214.
ProteinModelPortal	Q72LG3.
SMR	Q72LG3. Positions 2-335.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72LG3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2776274.
GenomeReviews	Gene locus TT_C0096 in contig AE017221_GR.
PATRIC	23950579. VBITheThe54392_0097.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0492.
HOGENOM	HBG669726.
OMA	FQVFELG.
PhylomeDB	Q72LG3.
ProtClustDB	CLSK738278.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C0096-MONOMER.
Family and domain databases
HAMAP	MF_01685. FENR2. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR022890. Fd--NADP_Rdtase_type_2. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
PANTHER	PTHR22912:SF53. PTHR22912:SF53. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProtoNet	Search...

Entry information

Entry name

FENR_THET2

Accession

Primary (citable) accession number: Q72LG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program