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Protein
Submitted name:

Thiosulfate reductase

Gene

TT_C0155

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Mo-bis(molybdopterin guanine dinucleotide)SAAS annotation
  • [4Fe-4S] clusterSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron-sulfur (4Fe-4S)Combined sources1
Metal bindingi47Iron-sulfur (4Fe-4S)Combined sources1
Metal bindingi51Iron-sulfur (4Fe-4S)Combined sources1
Metal bindingi79Iron-sulfur (4Fe-4S)Combined sources1
Binding sitei81Molybdopterin 2Combined sources1
Binding sitei145Molybdopterin 1Combined sources1
Binding sitei173Molybdopterin 1Combined sources1
Binding sitei173Molybdopterin 2Combined sources1
Binding sitei333Molybdopterin 1Combined sources1
Binding sitei445Molybdopterin 1Combined sources1
Binding sitei470Molybdopterin 1Combined sources1
Binding sitei482Molybdopterin 1Combined sources1
Binding sitei488Molybdopterin 1Combined sources1
Binding sitei625Molybdopterin 1Combined sources1
Binding sitei697Molybdopterin 1Combined sources1
Binding sitei735Molybdopterin 2Combined sources1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationImported

Keywords - Ligandi

4Fe-4SCombined sourcesSAAS annotation, Iron, Iron-sulfur, Metal-binding, MolybdenumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Thiosulfate reductaseImported (EC:1.-.-.-Imported)
Gene namesi
Ordered Locus Names:TT_C0155Imported
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)Imported
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-46375N.
STRINGi262724.TTC0155.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VPWX-ray3.10A/E1-765[»]
2VPXX-ray3.10A/E1-765[»]
2VPYX-ray2.50A/E1-765[»]
2VPZX-ray2.40A/E1-765[»]
ProteinModelPortaliQ72LA4.
SMRiQ72LA4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72LA4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 934Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni207 – 215Molybdopterin 2 bindingCombined sources9
Regioni235 – 238Molybdopterin 2 bindingCombined sources4
Regioni255 – 257Molybdopterin 2 bindingCombined sources3
Regioni331 – 337Molybdopterin 2 bindingCombined sources7
Regioni438 – 441Molybdopterin 1 bindingCombined sources4
Regioni465 – 466Molybdopterin 1 bindingCombined sources2
Regioni625 – 631Molybdopterin 2 bindingCombined sources7
Regioni632 – 633Molybdopterin 1 bindingCombined sources2
Regioni716 – 720Molybdopterin 1 bindingCombined sources5

Sequence similaritiesi

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107TG1. Bacteria.
COG0243. LUCA.
KOiK08352.
OMAiINERNHI.

Family and domain databases

InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72LA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRREFLKLS ALGVGAMALR GSGPAKALKA PWYAQEVKSV YQICEGCFWR
60 70 80 90 100
CGIVAHAVGN RVYKVEGYEA NPKSRGRLCP RGQGAPQTTY DPDRLKRPLI
110 120 130 140 150
RVEGSQRGEG KYRVATWEEA LDHIAKKMLE IREKYGPEAI AFFGHGTGDY
160 170 180 190 200
WFVDFLPAAW GSPNAAKPSV SLCTAPREVA SQWVFGRPIG GHEPIDWENA
210 220 230 240 250
RYIVLIGHHI GEDTHNTQLQ DFALALKNGA KVVVVDPRFS TAAAKAHRWL
260 270 280 290 300
PIKPGTDTAL LLAWIHVLIY EDLYDKEYVA KYTVGFEELK AHVKDFTPEW
310 320 330 340 350
AEKHTEIPAQ VIREVAREMA AHKPRAVLPP TRHNVWYGDD TYRVMALLYV
360 370 380 390 400
NVLLGNYGRP GGFYIAQSPY LEKYPLPPLP LEPAAGGCSG PSGGDHEPEG
410 420 430 440 450
FKPRADKGKF FARSTAIQEL IEPMITGEPY PIKGLFAYGI NLFHSIPNVP
460 470 480 490 500
RTKEALKNLD LYVAIDVLPQ EHVMWADVIL PEATYLERYD DFVLVAHKTP
510 520 530 540 550
FIQLRTPAHE PLFDTKPGWW IARELGLRLG LEQYFPWKTI EEYLETRLQS
560 570 580 590 600
LGLDLETMKG MGTLVQRGKP WLEDWEKEGR LPFGTASGKI ELYCQRFKEA
610 620 630 640 650
GHQPLPVFTP PEEPPEGFYR LLYGRSPVHT FARTQNNWVL MEMDPENEVW
660 670 680 690 700
IHKEEAKRLG LKEGDYVMLV NQDGVKEGPV RVKPTARIRK DCVYIVHGFG
710 720 730 740 750
HKAPLMRLAH GRGASDNYLQ TRYKLDPISG GAGLRVNFVR LEKAERPRLP
760
SLTGLAKRPF DERRM
Length:765
Mass (Da):86,614
Last modified:July 5, 2004 - v1
Checksum:i20400F2C2DF75E7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS80503.1.
RefSeqiWP_011172610.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS80503; AAS80503; TT_C0155.
KEGGitth:TT_C0155.
PATRICi23950701. VBITheThe54392_0155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS80503.1.
RefSeqiWP_011172610.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VPWX-ray3.10A/E1-765[»]
2VPXX-ray3.10A/E1-765[»]
2VPYX-ray2.50A/E1-765[»]
2VPZX-ray2.40A/E1-765[»]
ProteinModelPortaliQ72LA4.
SMRiQ72LA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46375N.
STRINGi262724.TTC0155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS80503; AAS80503; TT_C0155.
KEGGitth:TT_C0155.
PATRICi23950701. VBITheThe54392_0155.

Phylogenomic databases

eggNOGiENOG4107TG1. Bacteria.
COG0243. LUCA.
KOiK08352.
OMAiINERNHI.

Miscellaneous databases

EvolutionaryTraceiQ72LA4.

Family and domain databases

InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ72LA4_THET2
AccessioniPrimary (citable) accession number: Q72LA4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.