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Protein
Submitted name:

Thiosulfate reductase

Gene

TT_C0155

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Iron-sulfur (4Fe-4S)Combined sources
Metal bindingi47 – 471Iron-sulfur (4Fe-4S)Combined sources
Metal bindingi51 – 511Iron-sulfur (4Fe-4S)Combined sources
Metal bindingi79 – 791Iron-sulfur (4Fe-4S)Combined sources
Binding sitei81 – 811Molybdopterin 2Combined sources
Binding sitei145 – 1451Molybdopterin 1Combined sources
Binding sitei173 – 1731Molybdopterin 1Combined sources
Binding sitei173 – 1731Molybdopterin 2Combined sources
Binding sitei333 – 3331Molybdopterin 1Combined sources
Binding sitei445 – 4451Molybdopterin 1Combined sources
Binding sitei470 – 4701Molybdopterin 1Combined sources
Binding sitei482 – 4821Molybdopterin 1Combined sources
Binding sitei488 – 4881Molybdopterin 1Combined sources
Binding sitei625 – 6251Molybdopterin 1Combined sources
Binding sitei697 – 6971Molybdopterin 1Combined sources
Binding sitei735 – 7351Molybdopterin 2Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationImported

Keywords - Ligandi

4Fe-4SCombined sourcesSAAS annotation, Iron, Iron-sulfur, Metal-binding, MolybdenumSAAS annotation

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-159-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Thiosulfate reductaseImported (EC:1.-.-.-Imported)
Gene namesi
Ordered Locus Names:TT_C0155Imported
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)Imported
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-46375N.
STRINGi262724.TTC0155.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VPWX-ray3.10A/E1-765[»]
2VPXX-ray3.10A/E1-765[»]
2VPYX-ray2.50A/E1-765[»]
2VPZX-ray2.40A/E1-765[»]
ProteinModelPortaliQ72LA4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72LA4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 93574Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2159Molybdopterin 2 bindingCombined sources
Regioni235 – 2384Molybdopterin 2 bindingCombined sources
Regioni255 – 2573Molybdopterin 2 bindingCombined sources
Regioni331 – 3377Molybdopterin 2 bindingCombined sources
Regioni438 – 4414Molybdopterin 1 bindingCombined sources
Regioni465 – 4662Molybdopterin 1 bindingCombined sources
Regioni625 – 6317Molybdopterin 2 bindingCombined sources
Regioni632 – 6332Molybdopterin 1 bindingCombined sources
Regioni716 – 7205Molybdopterin 1 bindingCombined sources

Sequence similaritiesi

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.SAAS annotation
Contains 4Fe-4S Mo/W bis-MGD-type domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107TG1. Bacteria.
COG0243. LUCA.
KOiK08352.
OMAiINERNHI.
OrthoDBiEOG680WWV.

Family and domain databases

InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72LA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRREFLKLS ALGVGAMALR GSGPAKALKA PWYAQEVKSV YQICEGCFWR
60 70 80 90 100
CGIVAHAVGN RVYKVEGYEA NPKSRGRLCP RGQGAPQTTY DPDRLKRPLI
110 120 130 140 150
RVEGSQRGEG KYRVATWEEA LDHIAKKMLE IREKYGPEAI AFFGHGTGDY
160 170 180 190 200
WFVDFLPAAW GSPNAAKPSV SLCTAPREVA SQWVFGRPIG GHEPIDWENA
210 220 230 240 250
RYIVLIGHHI GEDTHNTQLQ DFALALKNGA KVVVVDPRFS TAAAKAHRWL
260 270 280 290 300
PIKPGTDTAL LLAWIHVLIY EDLYDKEYVA KYTVGFEELK AHVKDFTPEW
310 320 330 340 350
AEKHTEIPAQ VIREVAREMA AHKPRAVLPP TRHNVWYGDD TYRVMALLYV
360 370 380 390 400
NVLLGNYGRP GGFYIAQSPY LEKYPLPPLP LEPAAGGCSG PSGGDHEPEG
410 420 430 440 450
FKPRADKGKF FARSTAIQEL IEPMITGEPY PIKGLFAYGI NLFHSIPNVP
460 470 480 490 500
RTKEALKNLD LYVAIDVLPQ EHVMWADVIL PEATYLERYD DFVLVAHKTP
510 520 530 540 550
FIQLRTPAHE PLFDTKPGWW IARELGLRLG LEQYFPWKTI EEYLETRLQS
560 570 580 590 600
LGLDLETMKG MGTLVQRGKP WLEDWEKEGR LPFGTASGKI ELYCQRFKEA
610 620 630 640 650
GHQPLPVFTP PEEPPEGFYR LLYGRSPVHT FARTQNNWVL MEMDPENEVW
660 670 680 690 700
IHKEEAKRLG LKEGDYVMLV NQDGVKEGPV RVKPTARIRK DCVYIVHGFG
710 720 730 740 750
HKAPLMRLAH GRGASDNYLQ TRYKLDPISG GAGLRVNFVR LEKAERPRLP
760
SLTGLAKRPF DERRM
Length:765
Mass (Da):86,614
Last modified:July 5, 2004 - v1
Checksum:i20400F2C2DF75E7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS80503.1.
RefSeqiWP_011172610.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS80503; AAS80503; TT_C0155.
KEGGitth:TTC0155.
PATRICi23950701. VBITheThe54392_0155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS80503.1.
RefSeqiWP_011172610.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VPWX-ray3.10A/E1-765[»]
2VPXX-ray3.10A/E1-765[»]
2VPYX-ray2.50A/E1-765[»]
2VPZX-ray2.40A/E1-765[»]
ProteinModelPortaliQ72LA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46375N.
STRINGi262724.TTC0155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS80503; AAS80503; TT_C0155.
KEGGitth:TTC0155.
PATRICi23950701. VBITheThe54392_0155.

Phylogenomic databases

eggNOGiENOG4107TG1. Bacteria.
COG0243. LUCA.
KOiK08352.
OMAiINERNHI.
OrthoDBiEOG680WWV.

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-159-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ72LA4.

Family and domain databases

InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039Imported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR (4FE-4S) AND MOLYBDOPTERIN.

Entry informationi

Entry nameiQ72LA4_THET2
AccessioniPrimary (citable) accession number: Q72LA4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.