Q72KU1 (Q72KU1_THET2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441

Gene names

Ordered Locus Names:

TT_C0426

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195
Cofactor	Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195
Subunit structure	Homodimer By similarity. SAAS SAAS002195
Sequence similarities	Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis RuleBase RU003441 SAAS SAAS002195
Ligand	Metal-binding RuleBase RU003441 SAAS SAAS002195 Zinc RuleBase RU003441 SAAS SAAS002195
Molecular function	Hydrolase SAAS SAAS002195 RuleBase RU003441
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q72KU1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 55D31B1E4E410164	FASTA	426	45,592
	10 20 30 40 50 60 MILIRNVRLV DARGERGPAD VLIGEGRILS LEGGEAKQVV DGTGCFLAPG FLDLHAHLRE 70 80 90 100 110 120 PGEEVKEDLF SGLLAAVRGG YTDLVSMPNT KPPVDTPEAV RALKEKAKAL GLARLHPAAA 130 140 150 160 170 180 LTEKQEGKTL TPAGLLQEAG AVLLTDDGRT NEDAGVLAAG LLMAAPLGLP VAVHAEDAGL 190 200 210 220 230 240 RRNGVMNDGP LADLLGLPGN PPEAEAARIA RDLEVLRYAS RRSPATPRLH VQHLSTKRGL 250 260 270 280 290 300 ELIREAKRAG LPVTAEATPH HLTLTEEALR AFNPLFKVAP PLRGEEDREA LLEGLLDGTL 310 320 330 340 350 360 DAIATDHAPH TLAEKEKDLL RAPFGIPSLE VAFPLLYTEL HLKRGFPLPR LVELFTDGPR 370 380 390 400 410 420 RVLGLPPLHL EEGAEASLVL LSPKERPVDP SAFASKARYS PWAGWVLGGW PVLTLVAGRI VHEALK

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS80774.1.
RefSeq	YP_004401.1. NC_005835.1.
3D structure databases
ProteinModelPortal	Q72KU1.
SMR	Q72KU1. Positions 1-426.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72KU1.
Protein family/group databases
MEROPS	M38.972.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2775557.
GenomeReviews	Gene locus TT_C0426 in contig AE017221_GR.
PATRIC	23951251. VBITheThe54392_0424.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0044.
HOGENOM	HBG724623.
OMA	CDVHPVG.
PhylomeDB	Q72KU1.
ProtClustDB	PRK09357.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C0426-MONOMER.
Family and domain databases
HAMAP	MF_00220_B. PyrC_type2_B. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004722. DHOase. IPR002195. Dihydroorotase_CS. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR00857. PyrC_multi. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q72KU1_THET2

Accession

Primary (citable) accession number: Q72KU1

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)