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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:TT_C0427
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001132201 – 302Aspartate carbamoyltransferaseAdd BLAST302

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC0427.

Structurei

3D structure databases

ProteinModelPortaliQ72KU0.
SMRiQ72KU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
KOiK00609.
OMAiWCDVANM.

Family and domain databases

Gene3Di3.40.50.1370. 3 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR036901. Asp/Orn_carbamoylTrfase_sf.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
PANTHERiPTHR11405:SF16. PTHR11405:SF16. 1 hit.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72KU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLLDFQGW SRTEVESLLD TARVMREVLE RPIKKVPALQ GFTVATVFFE
60 70 80 90 100
PSTRTRISFE LAARRMSADV VSFAAQTSSL QKGESYKDTL LTLEAMGVDA
110 120 130 140 150
YVIRADSAGV PHQATRWVKG AVINGGDGRR AHPTQALLDA YTLLEALGTL
160 170 180 190 200
EGKKVAIVGD ILHSRVARSG AELLSLLGAQ VFCAGPPSLL PQSLPGAHLT
210 220 230 240 250
PRLEEALEEA DAVMVLRLQK ERMEAGLVHL EDYVARYQVT EKRLALAKPQ
260 270 280 290 300
APLLHPGPMN RDVELEGTLA DSARSLVNRQ VQNGVAVRMA VLYHLLVGRE

KA
Length:302
Mass (Da):33,015
Last modified:July 5, 2004 - v1
Checksum:i630EFD0E2237B709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS80775.1.
RefSeqiWP_011172874.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS80775; AAS80775; TT_C0427.
KEGGitth:TT_C0427.

Similar proteinsi

Entry informationi

Entry nameiPYRB_THET2
AccessioniPrimary (citable) accession number: Q72KU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome