Mannosyl-3-phosphogylcerate synthase - Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Mannosyl-3-phosphogylcerate synthase EMBL AAS80936.1
EC=2.4.1.- EMBL AAS80936.1

Gene names

Ordered Locus Names:

TT_C0588

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Magnesium PDB 2WVL PDB 2WVM Metal-binding PDB 2WVK PDB 2WVL PDB 2WVM Zinc PDB 2WVK PDB 2WVL PDB 2WVM
Molecular function	Glycosyltransferase EMBL AAS80936.1 Transferase
Technical term	3D-structure PDB 2WVK PDB 2WVL PDB 2WVM Complete proteome
Gene Ontology (GO)
Biological process	mannosylglycerate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	mannosyl-3-phosphoglycerate synthase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

8

1

Zinc 1; via tele nitrogen PDB 2WVK PDB 2WVL PDB 2WVM

Metal binding

8

1

Zinc 2; via pros nitrogen PDB 2WVK

Metal binding

19

1

Zinc 1 PDB 2WVK PDB 2WVL PDB 2WVM

Metal binding

19

1

Zinc 2 PDB 2WVK

Metal binding

169

1

Magnesium PDB 2WVM

Metal binding

242

1

Zinc 1 PDB 2WVK PDB 2WVL PDB 2WVM

Metal binding

251

1

Zinc 2 PDB 2WVK PDB 2WVL

Metal binding

251

1

Zinc 3 PDB 2WVK PDB 2WVL

Metal binding

292

1

Zinc 3 PDB 2WVK PDB 2WVL PDB 2WVM

Metal binding

296

1

Zinc 3; via tele nitrogen PDB 2WVK PDB 2WVL PDB 2WVM

Metal binding

309

1

Zinc 2; via pros nitrogen PDB 2WVK PDB 2WVL

Metal binding

309

1

Zinc 3; via pros nitrogen PDB 2WVK PDB 2WVL

Metal binding

311

1

Zinc 2; via tele nitrogen PDB 2WVK PDB 2WVL

Metal binding

311

1

Zinc 3; via tele nitrogen PDB 2WVK PDB 2WVL

Sequences

Sequence

Length

Mass (Da)

Tools

Q72K30 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B0829004B738FA9E
Show »

FASTA

391

43,594

        10         20         30         40         50         60 
MRLEIPNHTE RFGVVRLHEV QRILELDSGR VRDESPAVGL RRLDDADLRD VLEQTAIVVP 

        70         80         90        100        110        120 
TRNERLKLLE GVLSGIPHEA LILVASNSSP DRFQMERDLL EEFAHLTERP ALIFHQKDPA 

       130        140        150        160        170        180 
LAEALRAGGY PHPIGEDGLV RSGKAEGMIL ALVFAALSGR RYVGFIDADN YFPGAVWEYV 

       190        200        210        220        230        240 
RAYAAGFLMA KTPFAMVRIL WRYKPKLTED EGVVFRRYGR VSERNNRALN QLIGGVSGFE 

       250        260        270        280        290        300 
TDVVKTANAG EHAMSLGLAL RLPLASGYAV EPQELVSLLE LYGGVFPLED EEVLQHGVEI 

       310        320        330        340        350        360 
FQIETRNPHL HENKGDEHIR DMLLACLATV YHSKLATEEV RQSVLEELQA AGALAPGEEP 

       370        380        390 
PPPVLYPPLS SLDLQAVRKA LRGHFSRFRV P

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases." Goncalves S., Borges N., Esteves A.M., Victor B.L., Soares C.M., Santos H., Matias P.M. J. Biol. Chem. 285:17857-17868(2010) [PubMed: 20356840] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) IN COMPLEX WITH MAGNESIUM AND ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE017221 Genomic DNA. Translation: AAS80936.1.

RefSeq

YP_004563.1. NC_005835.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WVK	X-ray	2.97	A/B	1-391	[»]
2WVL	X-ray	2.81	A/B	1-391	[»]
2WVM	X-ray	2.98	A/B	1-391	[»]

ProteinModelPortal

Q72K30.

ModBase

Search...

Protein-protein interaction databases

STRING

Q72K30.

Protein family/group databases

CAZy

GT55. Glycosyltransferase Family 55.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

2776301.

GenomeReviews

Gene locus TT_C0588 in contig AE017221_GR.

PATRIC

23951581. VBITheThe54392_0586.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

NOG26569.

HOGENOM

HBG297698.

OMA

RVSEITN.

ProtClustDB

PRK14503.

Enzyme and pathway databases

BioCyc

TTHE262724:TT_C0588-MONOMER.

Family and domain databases

InterPro

IPR012812. Osmo_MPG_synth.
[Graphical view]

Pfam

PF09488. Osmo_MPGsynth. 1 hit.
[Graphical view]

TIGRFAMs

TIGR02460. Osmo_MPGsynth. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q72K30_THET2

Accession

Primary (citable) accession number: Q72K30

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)