Q72JT8 (Q72JT8_THET2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Anti-cleavage anti-greA transcription factor gfh1 EMBL AAS81028.1

Gene names

Name:	greA EMBL AAS81028.1
Ordered Locus Names:	TT_C0680

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as greA or greB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides By similarity. SAAS SAAS018151

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS001437
Ligand	DNA-binding SAAS SAAS001437
Technical term	3D-structure PDB 2F23 Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription elongation, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q72JT8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2B7BAF660E8ECE14	FASTA	156	17,155
	10 20 30 40 50 60 MAREVKLTKA GYERLMQQLE RERERLQEAT KILQELMESS DDYDDSGLEA AKQEKARIEA 70 80 90 100 110 120 RIDSLEDILS RAVILEEGSG EVIGLGSVVE LEDPLSGERL SVQVVSPAEA NVLDTPMKIS 130 140 150 DASPMGKALL GHRVGDVLSL DTPKGKREFR VVAIHG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"pH-dependent conformational switch activates the inhibitor of transcription elongation." Laptenko O., Kim S.S., Lee J., Starodubtseva M., Cava F., Berenguer J., Kong X.P., Borukhov S. EMBO J. 25:2131-2141(2006) [PubMed: 16628221] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE017221 Genomic DNA. Translation: AAS81028.1.

RefSeq

YP_004655.1. NC_005835.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2F23	X-ray	1.60	A/B	1-156	[»]

ProteinModelPortal

Q72JT8.

SMR

Q72JT8. Positions 3-156.

ModBase

Search...

Protein-protein interaction databases

STRING

Q72JT8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

2776471.

GenomeReviews

Gene locus TT_C0680 in contig AE017221_GR.

PATRIC

23951765. VBITheThe54392_0677.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG0782.

HOGENOM

HBG753387.

OMA

QMETSAD.

ProtClustDB

CLSK2761922.

Enzyme and pathway databases

BioCyc

TTHE262724:TT_C0680-MONOMER.

Family and domain databases

InterPro

IPR018151. TF_GreA/GreB_CS.
IPR023459. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]

Gene3D

G3DSA:1.10.287.180. GreA_GreB_reg. 1 hit.
G3DSA:3.10.50.30. GreA_GreB_reg. 1 hit.

Pfam

PF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]

PIRSF

PIRSF006092. GreA_GreB. 1 hit.

SUPFAM

SSF46557. GreA_GreB. 1 hit.

PROSITE

PS00830. GREAB_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q72JT8_THET2

Accession

Primary (citable) accession number: Q72JT8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)