Q72J47 (RPIA_THET2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-5-phosphate isomerase A
EC=5.3.1.6

Alternative name(s):
Phosphoriboisomerase A
Short name=PRI

Gene names

Name:	rpiA
Ordered Locus Names:	TT_C0932

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP MF_00170
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: InterPro
Molecular function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 227

227

Ribose-5-phosphate isomerase A HAMAP MF_00170

PRO_0000158486

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

227

Helix Strand Turn

Details...

Helix

6 – 17

12

Beta strand

25 – 28

4

Helix

32 – 46

15

Beta strand

54 – 59

6

Helix

60 – 68

9

Beta strand

81 – 86

6

Beta strand

89 – 92

4

Helix

93 – 95

3

Beta strand

96 – 98

3

Helix

105 – 113

9

Beta strand

115 – 123

9

Helix

124 – 126

3

Beta strand

129 – 131

3

Beta strand

136 – 140

5

Helix

145 – 154

10

Beta strand

159 – 161

3

Beta strand

176 – 180

5

Helix

188 – 196

9

Beta strand

201 – 207

7

Beta strand

212 – 218

7

Beta strand

221 – 225

5

Sequences

	Sequence		Length	Mass (Da)
	Q72J47 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 47CD743AEAC126C7	FASTA	227	24,039
	10 20 30 40 50 60 MERPLESYKK EAAHAAIAYV QDGMVVGLGT GSTARYAVLE LARRLREGEL KGVVGVPTSR 70 80 90 100 110 120 ATEELAKREG IPLVDLPPEG VDLAIDGADE IAPGLALIKG MGGALLREKI VERAAKEFIV 130 140 150 160 170 180 IADHTKKVPV LGRGPVPVEI VPFGYRATLK AIADLGGEPE LRMDGDEFYF TDGGHLIADC 190 200 210 220 RFGPIGDPLG LHRALLEIPG VVETGLFVGM ATRALVAGPF GVEELLP

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB27 / ATCC BAA-163 / DSM 7039.

+

Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE017221 Genomic DNA. Translation: AAS81276.1.

RefSeq

YP_004903.1. NC_005835.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UJ4	X-ray	1.80	A	1-227	[»]
1UJ5	X-ray	2.00	A	1-227	[»]
1UJ6	X-ray	1.74	A	1-227	[»]

ProteinModelPortal

Q72J47.

SMR

Q72J47. Positions 3-227.

ModBase

Search...

Protein-protein interaction databases

STRING

Q72J47.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

2775125.

GenomeReviews

Gene locus TT_C0932 in contig AE017221_GR.

PATRIC

23952267. VBITheThe54392_0926.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG0120.

HOGENOM

HBG515603.

OMA

GGDPEYR.

PhylomeDB

Q72J47.

ProtClustDB

PRK00702.

Enzyme and pathway databases

BioCyc

TTHE262724:TT_C0932-MONOMER.

Family and domain databases

HAMAP

MF_00170. Rib_5P_isom_A.
[Tree]

InterPro

IPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]

PANTHER

PTHR11934. RpiA. 1 hit.

Pfam

PF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00021. RpiA. 1 hit.

ProtoNet

Search...

Entry information

Entry name

RPIA_THET2

Accession

Primary (citable) accession number: Q72J47

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program