Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 7815-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei103 – 10315-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei193 – 1931Uracil; via amide nitrogenUniRule annotation
Binding sitei199 – 19915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-956-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:TT_C0946
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Uracil phosphoribosyltransferasePRO_0000120905Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC0946.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Helixi9 – 1911Combined sources
Helixi25 – 4319Combined sources
Turni44 – 463Combined sources
Beta strandi49 – 557Combined sources
Beta strandi57 – 6610Combined sources
Beta strandi72 – 765Combined sources
Turni77 – 793Combined sources
Helixi80 – 889Combined sources
Beta strandi95 – 1017Combined sources
Turni105 – 1073Combined sources
Beta strandi113 – 1164Combined sources
Helixi121 – 1233Combined sources
Beta strandi126 – 1294Combined sources
Beta strandi131 – 1366Combined sources
Helixi137 – 14812Combined sources
Beta strandi155 – 1617Combined sources
Helixi163 – 17210Combined sources
Beta strandi177 – 1837Combined sources
Beta strandi185 – 1873Combined sources
Beta strandi193 – 1964Combined sources
Helixi200 – 2056Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V9SX-ray2.10A/B/C/D1-208[»]
ProteinModelPortaliQ72J35.
SMRiQ72J35. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ72J35.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 13895-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
Regioni198 – 2003Uracil bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ5. Bacteria.
COG0035. LUCA.
KOiK00761.
OMAiVTVIDHP.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
PfamiPF14681. UPRTase. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72J35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRITLVDHPL VQHKLAHLRD KRTGPKDFRE LAEEVAMLMA YEAMRDLELE
60 70 80 90 100
ETTVETPIAP ARVKVLSGKK LALVAILRAG LVMVEGILKL VPHARVGHIG
110 120 130 140 150
LYRDPESLNP VQYYIKLPPD IAERRAFLLD PMLATGGSAS LALSLLKERG
160 170 180 190 200
ATGVKLMAIL AAPEGLERIA KDHPDTEVVV AAIDERLNDH GYIVPGLGDA

GDRIYGTK
Length:208
Mass (Da):22,762
Last modified:July 5, 2004 - v1
Checksum:iA4864A09141522C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81288.1.
RefSeqiWP_011173367.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81288; AAS81288; TT_C0946.
KEGGitth:TTC0946.
PATRICi23952295. VBITheThe54392_0940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81288.1.
RefSeqiWP_011173367.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V9SX-ray2.10A/B/C/D1-208[»]
ProteinModelPortaliQ72J35.
SMRiQ72J35. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC0946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS81288; AAS81288; TT_C0946.
KEGGitth:TTC0946.
PATRICi23952295. VBITheThe54392_0940.

Phylogenomic databases

eggNOGiENOG4105CZ5. Bacteria.
COG0035. LUCA.
KOiK00761.
OMAiVTVIDHP.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00636.
BioCyciTTHE262724:GCAT-956-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ72J35.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
PfamiPF14681. UPRTase. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUPP_THET2
AccessioniPrimary (citable) accession number: Q72J35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.