Q72IQ9 (COMB_THET2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	TT_C1073

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_0000081478

Sequences

	Sequence		Length	Mass (Da)
	Q72IQ9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 94DE8619E5C9A6BE	FASTA	237	24,768
	10 20 30 40 50 60 MRLRVDVIPG EHLAYPDVVL VVDVIRATTT AAAFLEAGAE ALYWTPSLES ALAFKDEDVV 70 80 90 100 110 120 LAGETGGLKP PRFDLGNSPR EALSAQVAGR VVVMSTTNGT KAAHAAARTA KHVLLASLYN 130 140 150 160 170 180 AHAAARLARE LATEEVAILC AGKEGRAGLD DLYTAGVLAE YLGFLGEVEP EDGARVALAV 190 200 210 220 230 KRAYPDPLEA LSLSAAALAL KQVGLEADVP FCAQVAKSTA VPVLRGRVGE ALIFKRA

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB27 / ATCC BAA-163 / DSM 7039.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017221 Genomic DNA. Translation: AAS81415.1.
RefSeq	YP_005042.1. NC_005835.1.
3D structure databases
ProteinModelPortal	Q72IQ9.
SMR	Q72IQ9. Positions 1-237.
ModBase	Search...
Protein-protein interaction databases
STRING	Q72IQ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2775113.
GenomeReviews	Gene locus TT_C1073 in contig AE017221_GR.
PATRIC	23952547. VBITheThe54392_1064.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2045.
HOGENOM	HBG633644.
OMA	VMSTTNG.
PhylomeDB	Q72IQ9.
ProtClustDB	PRK14100.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C1073-MONOMER.
Family and domain databases
HAMAP	MF_00490. ComB. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. IPR022995. Pase_ComB. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
SUPFAM	SSF142823. SSF142823. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_THET2

Accession

Primary (citable) accession number: Q72IQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program