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Protein

Guanylate kinase

Gene

gmk

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:TT_C1197
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001706311 – 220Guanylate kinaseAdd BLAST220

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1197.

Structurei

3D structure databases

ProteinModelPortaliQ72ID5.
SMRiQ72ID5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 180Guanylate kinase-likeUniRule annotationAdd BLAST178

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
KOiK00942.
OMAiAGNYYGT.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q72ID5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGRLFVMTG ASGVGKGTVR AKVLERTRLF YSISMTTRPP RPGEVDGVDY
60 70 80 90 100
YFVDRPTFEA LVREDGFLEY AEYVGHLYGT PRAPVERALS RGEDVLLEIE
110 120 130 140 150
VQGALQVKRA VPEAVLIFLL PPSLSELKRR LVYRGKDSPE KIQKRLEQAE
160 170 180 190 200
WEIRNAHLFD YVVVNDVLEE AVADFLAILT AERRRSGRMG EALEMALRRD
210 220
LALEAELDEI LRRRYGGTGH
Length:220
Mass (Da):25,022
Last modified:July 5, 2004 - v1
Checksum:i1463636A06674E6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS81539.1.
RefSeqiWP_008633187.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81539; AAS81539; TT_C1197.
KEGGitth:TT_C1197.

Similar proteinsi

Entry informationi

Entry nameiKGUA_THET2
AccessioniPrimary (citable) accession number: Q72ID5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome