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Q72I77

- TRMB_THET2

UniProt

Q72I77 - TRMB_THET2

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281S-adenosyl-L-methionineUniRule annotation
Binding sitei53 – 531S-adenosyl-L-methionineUniRule annotation
Active sitei103 – 1031By similarity
Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation
Binding sitei107 – 1071SubstrateUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1270-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:TT_C1255
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311tRNA (guanine-N(7)-)-methyltransferasePRO_0000171414Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1255.

Structurei

3D structure databases

ProteinModelPortaliQ72I77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiTKYALKW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q72I77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVVPARLHR WPPEVQDLFG REGPLVLEIG FGDGRFTAEL ARSRPDWLVL
60 70 80 90 100
GAEVSAASVL RALRRMRREG LANVRLYHGQ GPFALRNLVL PGTLDQVIVN
110 120 130 140 150
FPDPWPKKRH QERRLLREAF FRRLSTRLKS GGSLLLTTDH EGYFRFALEE
160 170 180 190 200
AERTGLYRVE VRPPPEAHLR TKYALKWKEA GRTFFHAAFI KLREDPAPWP
210 220 230 240 250
PLRRYDVAHA LLSGELPQDL ALEKTAVRLK EGVAVFLEVA RGKEGFYVLT
260 270 280 290 300
HVEEEDLTQD LLLEVRKSAR GVYAGVSRFG SPLITEAVKG AVRALVDRLE
310
AHGLEVVQDH T
Length:311
Mass (Da):35,297
Last modified:July 5, 2004 - v1
Checksum:i6400326DF6AD3FDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81597.1.
RefSeqiYP_005224.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81597; AAS81597; TT_C1255.
GeneIDi2774621.
KEGGitth:TTC1255.
PATRICi23952917. VBITheThe54392_1247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81597.1 .
RefSeqi YP_005224.1. NC_005835.1.

3D structure databases

ProteinModelPortali Q72I77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1255.

Protocols and materials databases

DNASUi 2774621.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS81597 ; AAS81597 ; TT_C1255 .
GeneIDi 2774621.
KEGGi tth:TTC1255.
PATRICi 23952917. VBITheThe54392_1247.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi TKYALKW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci TTHE262724:GCAT-1270-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiTRMB_THET2
AccessioniPrimary (citable) accession number: Q72I77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3