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Q72I77

- TRMB_THET2

UniProt

Q72I77 - TRMB_THET2

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281S-adenosyl-L-methionineUniRule annotation
    Binding sitei53 – 531S-adenosyl-L-methionineUniRule annotation
    Active sitei103 – 1031By similarity
    Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation
    Binding sitei107 – 1071SubstrateUniRule annotation
    Binding sitei139 – 1391SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1270-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:TT_C1255
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311tRNA (guanine-N(7)-)-methyltransferasePRO_0000171414Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262724.TTC1255.

    Structurei

    3D structure databases

    ProteinModelPortaliQ72I77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiTKYALKW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q72I77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVVPARLHR WPPEVQDLFG REGPLVLEIG FGDGRFTAEL ARSRPDWLVL    50
    GAEVSAASVL RALRRMRREG LANVRLYHGQ GPFALRNLVL PGTLDQVIVN 100
    FPDPWPKKRH QERRLLREAF FRRLSTRLKS GGSLLLTTDH EGYFRFALEE 150
    AERTGLYRVE VRPPPEAHLR TKYALKWKEA GRTFFHAAFI KLREDPAPWP 200
    PLRRYDVAHA LLSGELPQDL ALEKTAVRLK EGVAVFLEVA RGKEGFYVLT 250
    HVEEEDLTQD LLLEVRKSAR GVYAGVSRFG SPLITEAVKG AVRALVDRLE 300
    AHGLEVVQDH T 311
    Length:311
    Mass (Da):35,297
    Last modified:July 5, 2004 - v1
    Checksum:i6400326DF6AD3FDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81597.1.
    RefSeqiWP_011173656.1. NC_005835.1.
    YP_005224.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS81597; AAS81597; TT_C1255.
    GeneIDi2774621.
    KEGGitth:TTC1255.
    PATRICi23952917. VBITheThe54392_1247.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81597.1 .
    RefSeqi WP_011173656.1. NC_005835.1.
    YP_005224.1. NC_005835.1.

    3D structure databases

    ProteinModelPortali Q72I77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TTC1255.

    Protocols and materials databases

    DNASUi 2774621.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS81597 ; AAS81597 ; TT_C1255 .
    GeneIDi 2774621.
    KEGGi tth:TTC1255.
    PATRICi 23952917. VBITheThe54392_1247.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi TKYALKW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci TTHE262724:GCAT-1270-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.

    Entry informationi

    Entry nameiTRMB_THET2
    AccessioniPrimary (citable) accession number: Q72I77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3